Hypothemycin

供应商 ：Neobioscience

CAS号 ：76958-67-3

保存条件 ：-20

规格 ：1 x 250.0 x µg

Exhibits antifungal and cytotoxic activity against some tumor cell lines partly attributed to inhibition of Ras-inducible genes. Inhibits proliferation of mouse and human T cells and modulates production of cytokines during T cell activation. Facilitates the ubiquitinylation process of cyclin D1. Has been identified as a potent and selective inhibitor of threonine/tyrosine-specific kinase, MEK, and other protein kinases that contain a conserved cysteine residue in the ATP-binding site in both in vitro and in vivo studies. Hypothemycin inhibited the growth of HT29 and HCT116 cells in serum-free defined medium. IC₅₀ at 0.078 mM and 0.90 mM, respectively.
Hypothemycin concurrently inhibitis Kit- and Fc^εRI-mediated signaling.