DAPT

保质期 ：2 years

英文名 ：DAPT

库存 ：10

供应商 ：上海伟进生物科技有限公司

CAS号 ：208255-80-5

保存条件 ：-20℃

规格 ：5mg

Biological Activity

DAPT is a functional γ-secretase inhibitor and significantly reduces the production of total Aβ and Aβ42 in human primary neuronal cultures (IC₅₀= 115 nM for total Aβ, IC₅₀= 200 nM for Aβ42) ^[1], as well as in brain extract, CSF, and the plasma in vivo dose- and time-dependently ^[2]. DAPT efficiently blocks Notch signaling in hybrid human-mouse fetal thymus organ culture (FTOC) ^[3]. DAPT decreases lymphoproliferation in CBA-lpr mice and autoimmunity in MRL-lpr mice. By using a novel intermittent low-dose schedule, DAPT is well tolerated for months and the reported side effects of γ-secretase inhibitor are avoided ^[4]. DAPT-mediated suppression of Notch response enhances neuronal differentiation in ESCs-derived embryoid bodies (EBs) independently of SHH signaling ^[5].

Chemical Properties

Cas No.: 208255-80-5	M. Wt.: 432.46
Formula: C23H26F2N2O4	Purity: >98.5%
Synonym: GSI-IX, LY-374973
Chemical Name: N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester
Appearance: White solid
Solubility: Soluble in DMSO (85 mg/mL) and in ethanol (50 mg/mL). Slightly soluble in water (<1 mg/ml).
Storage: Store solid at -20 ºC for the stability of two years