Quercetin

保质期 ：2 years

英文名 ：Quercetin

库存 ：10

供应商 ：上海伟进生物科技有限公司

CAS号 ：117-39-5

保存条件 ：-20℃

规格 ：100mg

Biological Activity

Quercetin is a plant-derived flavonoid molecule ubiquitous in nature, displaying potential anti- cancer activity. Quercetin time- and dose-dependently down-regulates the expression of mutant p53 protein at the translational level and arrests cells in the G2-M phase, thereby suppressing cell proliferation (IC₅₀= 7 µg/mL) in human breast cancer cell lines ^[1]. It also arrests human leukemic T-cells in the late G1 phase ^[2]. Quercetin inhibits the activity of various enzymes, including tyrosine protein kinase (Trk)^[3], Phospholipase A2 ^[4], cyclooxygenase 2 ^[5], monoamine-oxidase ^[6], ornithine decarboxylase ^[7], 5-lypooxigenase, protein kinase C, and mitochondrial ATPase. Quercetin markedly inhibits PI3K-Akt/PKB pathway in a manner similar to that of the selective PI3K inhibitor LY294002 ^[8]. Quercetin also acts as a GPR30 (G protein-coupled estrogen receptor) activator ^[9]. Quercetin has been used as an antioxidant in the treatment of inflammatory diseases and been investigated in several clinical trials.

Chemical Properties

Cas No.: 117-39-5	M. Wt.: 302.24
Formula: C15H10O7	Purity: ≥95% (HPLC)
Synonym: Sophoretin
Chemical Name: 2-(3,4-Dihydroxyphenyl)-3,5,7-trihy­droxy-4H-1-benzopyran-4-one
Appearance: Yellow to yellow-green powder
Solubility: Soluble to 100 mM in DMSO
Storage: Store powder at RT