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保质期 :2 years
英文名 :Rapamycin
库存 :10
供应商 :上海伟进生物科技有限公司
CAS号 :53123-88-9
保存条件 :-20℃
规格 :10mg/50mg/100mg
Biological Activity
Rapamycin (also known as Sirolimus and AY-22989), is a highly potent immunosuppressant used primarily to prevent rejection in organ and bone marrow transplant. Rapamycin specifically binds to immunophilin, FK binding protein-12 (FKBP-12) to form a complex that directly binds to FRB domain of mTOR and thus inhibits its activity [1-3]. In IL-2-stimulated T cells, Rapamycin impedes cell progression through the G1/S transition of the proliferation cycle,resulting in a mid-to-late G1 arrest via two major mechanism of action, first the Rapamycin-FKBP-mTOR complex blocks the phosphorylation/activation of the 70 kd S6 protein kinases (pp70S6K), an early event of cytokine-induced mitogenic response; A second the complex suppresses the enzymatic activity of the cyclin-dependent kinase cdk2-cyclin E complex, which functions as a crucial regulator of G1/S transition [4-5]. Rapamycin shows antitumor properties by halting tumor cell proliferation, inducing tumor cell apoptosis, and suppressing tumor angiogenesis [6]. Rapamycin extends median and maximal lifespan of both male and female mice when feed beginning at 600 days of age [7]. [Note: Rapamycin sold by Gene Operation is for scientific research use only, not for human and veterinary use.]
Chemical Properties
Cas No.: 53123-88-9 |
M. Wt.: 914.17 |
Formula: C51H79NO13 |
Purity: >99% |
Synonym: Sirolimus, AY-22989, RAPA, NSC 226080, Rapamune® |
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Chemical Name: (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25, 26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]- 1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone |
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Appearance: White to off-white crystalline powder |
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Solubility: Soluble in DMSO and ethanol at 50 mg/mL. Very poorly soluble in water. |
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Storage: Store powder at -20 ºC for the stability up to two years. |
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入驻年限:16年