Torin 1

保质期 ：2 years

英文名 ：Torin 1

库存 ：10

供应商 ：上海伟进生物科技有限公司

CAS号 ：1222998-36-8

保存条件 ：-20℃

规格 ：5mg

Biological Activity

Torin 1, a member of the pyridinonequinoline class of kinase inhibitors, is a highly selective and ATP-competitive inhibitor of mTOR, with IC₅₀ values between 2 and 10 nM for mTORC1 and mTORC2 both in vitro kinase and whole cell assays. Torin 1 exhibits at least 200-fold selectivity for mTOR over related hVps34 (IC₅₀, 3 μM), PI3Kα (IC₅₀, 1.8 μM), DNA-PK (IC₅₀, 1.0 μM) and ATM (0.6 μM).Torin1 causes cell cycle arrest through a rapamycin-resistant mechanism that is also independent of mTORC2. The compound shows a far greater degree than rapamycin in the suppression of cell growth and proliferation ^[1]. Torin 1, at a dose of 20 mg/kg, effectively inhibits tumor growth in a U87MG xenograft model and demonstrates good pharmacodynamic inhibition of downstream effectors of mTOR in tumor and peripheral tissues ^[2].

Chemical Properties

Cas No.: 1222998-36-8	M. Wt.: 607.62
Formula: C35H28F3N5O2	Purity: >98%
Synonym: tricyclic benzonaphthyridinone inhibitor 37
Chemical Name: 1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one
Appearance: A crystalline solid
Solubility: Soluble in DMSO at 1mM
Storage: Store solid at -20 ºC for the stability of 2 years

Application Concentration (Just for reference)

The appropriate working concentration of Torin 1 depends on cell types, cell culture properties and specific applications. It is recommended that researchers start with optimal experiments for first use.