Catalog Number:

AF-315-05

Synonyms:

Immune Interferon, type II interferon, T cell interferon, MAF

Description:

IFN-γ是一种对酸不稳定的干扰素，由CD4﹢和CD8﹢ T淋巴细胞及活化的NK细胞产生。IFN-γ受体存在于多种免疫细胞上，这些细胞通过增加MHC I类蛋白在细胞表面的表达对IFN-γ信号作出应答。这将促进辅助性T细胞（CD4+）对抗原的递呈作用。抗原递呈细胞和识别抗原的B和T淋巴细胞中的IFN-γ信号调节免疫反应的抗原特异性阶段。此外，IFN-γ可刺激多种淋巴样细胞功能，包括巨噬细胞，NK细胞，中性粒细胞的抗微生物和抗肿瘤功能。人IFN-γ具有种属特异性，只对人类和灵长类动物细胞有生物活性。重组小鼠IFN-γ是一种15.6 kDa的蛋白，包含134个氨基酸残基。生产过程中的所有试剂均为非动物源性。

AA Sequence:

MHGTVIESLE SLNNYFNSSG IDVEEKSLFL DIWRNWQKDG DMKILQSQII SFYLRLFEVL KDNQAISNNI SVIESHLITT FFSNSKAKKD AFMSIAKFEV NNPQVQRQAF NELIRVVHQL LPESSLRKRK RSRC

Source:

E.coli

Purity:

Greater than 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity:

Determined by its ability to inhibit the proliferation of murine WEHI-279 cells. The expected ED50 is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106 units/mg.

Research Interests:

	AIDS / HIV		Angiogenesis/ Cardiovascular
	Cancer		Diabetes / Weight Regulation
	Immune System		Neurobiology
	Stem Cells & Differentiation		Allergy
	Transplantation

Country of Origin:

USA