TGFß 信号靶标PCR 芯片TGFß Signaling Targets PCR Array

服务名称 ：PCR芯片

提供商 ：SABio

TGFß信号靶标PCR芯片可用于研究84个TGFß信号转导应答关键基因的表达。TGFß超级家族由4个信号通路组成：TGFß，成骨蛋白（BMP），Activin，Nodal。这些通路调节多种细胞活动，如发育和分化，细胞增殖和迁移，细胞凋亡和细胞周期调控。SMAD转录因子受TGFß配体（TGFßs，BMPs，生长分化因子及其它）活化后入核与另外的转录因子作用从而激活特定的靶标基因。TGFß信号转导通路的失调与如纤维症或癌症等疾病的发生相关联。各种实验技术如表达谱分析、ChIP和转录因子结合位点的生物信息学预测已鉴定得出了大量的TGFß靶标基因。该芯片则涵盖了TGFß转录因子和多种实验验证得到的高度相关性靶标基因，芯片结果可用来分析TGFß信号传导的激活或抑制。通过实时定量PCR，研究者可以简单可靠地同时分析参与TGFß关联细胞活动的基因表达。

Product	Species	Technology	Cat. No.
TGFß Signaling Targets PCR Array	Human	Gene Expression	PAHS-235Z
TGFß Signaling Targets PCR Array	Mouse	Gene Expression	PAMM-235Z
TGFß Signaling Targets PCR Array	Rat	Gene Expression	PARN-235Z
TGFß Signaling Targets PCR Array	Pig	Gene Expression	PASS-235Z

Differentiation & Development: Regulation: AGT, BDNF, CTNNB1, EPHB2, HES1, KLF10, NFKBIA (IkBa/MAD3), PPARA, PTHLH, PTK2, RARA, RHOA, RUNX1 (AML1), SHH, TGFB2, TGFBR2. Other Genes: BRD2, CEBPB, CREB1, DNAJA1, EMP1, ENG (EVI-1), FN1, IFRD1, MAPK14 (p38 MAPK), MMP2 (Gelatinase A), MYOD1, SNAI1. Proliferation & Migration: Regulation: ACVRL1 (ALK1), AGT, ATF3, BCL2L1 (BCL-X), BDNF, CDC6, CDKN1B (p27KIP1), CTNNB1, FURIN, HES1, HMOX1, IL10, KLF10, MSX2, MYC, NFKBIA (IkBa/MAD3), PDGFA, PLG, PTGS2 (COX-2), PTHLH, PTK2B, SERPINE1 (PAI-1), SHH, SOX4, TGFB2, TGFBR2, THBS1, TXNIP, VEGFA. Other Genes: ACTA2(a-SMA), ACVR1 (ALK2), AR, EMP1, FN1, FURIN, IL10, PTK2. Apoptosis: ACVR1 (ALK2), AGT, AIPL1, CDKN1B (p27KIP1), CREB1, CTNNB1, FURIN, GADD45B, HERPUD1, KLF10, MAP3K7 (TAK1), MAPK8 (JNK1), MSX2, PLG, PTGS2 (COX-2), RAD21, RHOA, RHOB, RYBP, S100A8, SHH, SOX4, TGFB2, TNFSF10 (TRAIL), TXNIP. Anti-Apoptosis: BCL2L1 (BCL-X), BDNF, CEBPB, CRYAB, HMOX1, IL10, NFKBIA (IkBa/MAD3), PTK2B, THBS1, VEGFA. Cell Cycle: Regulation: ACVR1 (ALK2), RAD21. Other Genes: CDC6, CDKN1B (p27KIP1), GADD45B, PTGS2 (COX-2), RHOB, TGFB2. Signal Transduction: TGFß Pathway: ACVR1 (ALK2), ACVRL1 (ALK1), CREBBP (CBP), E2F4, ENG (EVI-1), EP300, ID1, ID2, ID3, MSX2, RBL1, SMAD1, SMAD3, SMAD5, SMAD6, SP1, TGFB2, TGFBR2, THBS1. NF?B Pathway: HMOX1, IL10, MAP3K7 (TAK1), NFKBIA (IkBa/MAD3), RHOA, TNFSF10 (TRAIL). Notch Pathway: HES1, HEY1, NOTCH1. Hedgehog Pathway: GLI2, SHH. Wnt Pathway: CTNNB1. Transcription Factors: TGFß Signaling: CREBBP (CBP), E2F4, EP300, ID1, ID2, ID3, RBL1, SMAD1, SMAD3, SMAD5, SMAD6, SP1. Others: AR, ATF3, ATF4, BACH1, BHLHE40, CEBPB, CREB1, CTNNB1, FOS, GTF2I, HEY1, KLF10, MBD1, MSX2, MYC, MYOD1, NFIB, PPARA, RARA, RUNX1 (AML1), SOX4, SREBF2.