AssayPro—Mouse beta 2-Microglobulin ELISA Kit（小鼠β2微球蛋白β2-MG酶联免疫试剂盒）

Introduction
β2-Microglobulin (β2M) is a small serum protein that constitutes thelight chain of the major histocompatibility class I human leukocyteantigen (HLA class I), an integral membrane protein involved in theimmune response. The protein is 99 amino acid residues in length and hasmolecular mass of 12 kDa (1 - 4). β2M is released from the cell surfaceof HLA class I into the serum and carried to the kidneys for degradationand secretion (5). In chronic renal failure, β2M accumulates asinsoluble amyloid aggregates and causes arthralgias, destructiveosteoarthropathies, carpal tunnel syndrome and dialysis-relatedamyloidosis (6 - 8). Elevated serum β2M levels are associated with poorprognosis in multiple myeloma and lymphoma (9 - 12).