AssayPro—Human Kininogen (HMW) ELISA Kit（高分子量激肽原KNG酶联免疫试剂盒）

AssayMax Human Kininogen (HMW) ELISA Kit
高分子量激肽原KNG酶联免疫试剂盒

Introduction

High molecular-weight kininogen (HK) is a plasma protein coagulation cofactor serving for the activation of zymogens prekallikrein, Factor XII, and Factor XI and is also a substrate of each of their proteolytic forms. It circulates as a complex with these zymogens and links the plasma coagulation, fibrinolysis, complement activation, and blood pressure control. HK is produced by the liver and weighs 120 kDa with 626 amino acids. Its plasma concentration ranges from 55 to 90 μg/ml and (1, 5). HK exhibits anticoagulant properties and is a strong inhibitor of cysteine proteases. Upon cleavage by kallikrein, the released active peptide bradykinin mediates NO release, vasodilation, hypotension, and pain. The remaining cleaved HK (HKa) exhibits antiadhesive and antiangiogenic activity, enhancing cell-associated fibrinolysis and releasing cytokines and chemokines to enhance inflammation. Patients with HK deficiency exhibit abnormal surface-mediated activation of fibrinolysis (6, 7).