PE anti-human CD279 (PD-1)

抗体名 ：PE anti-human CD279 (PD-1)

是否单克隆 ：单克隆

抗体英文名 ：PE anti-human CD279 (PD-1)

应用范围 ：流式

抗原来源 ：人，大小鼠

宿主 ：小鼠

规格 ：25T

PE anti-human CD279 (PD-1)
Description

Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 (B7-H1) and PD-L2 (B7-DC) are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.