磷酸化mTOR(Ser2448)抗体，Phospho-mTOR (Ser2448) Antibody

价格： ¥1200

品牌：affinity

货号：AF3308

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抗体名：磷酸化mTOR(Ser2448)抗体

抗原来源：人，大小鼠

是否单克隆：多克隆

抗体英文名：Phospho-mTOR (Ser2448) Antibody

宿主：Rabbit

适应物种：Human, Mouse, Rat, Fish

规格：50ul

磷酸化mTOR(Ser2448)抗体，Phospho-mTOR (Ser2448) Antibody

名称:
磷酸化 mTOR (Ser2448) 抗体
货号:
AF3308
来源:
Rabbit
应用:
WB,IHC,ELISA
反应:
Human, Mouse, Rat, Fish
预测:
Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(100%)
蛋白号:
P42345
分子量:
250-289 kDa
浓度:
1mg/ml

Alternative Names:Expand▼

dJ576K7.1 (FK506 binding protein 12 rapamycin associated protein 1); FK506 binding protein 12 rapamycin associated protein 1; FK506 binding protein 12 rapamycin associated protein 2; FK506 binding protein 12 rapamycin complex associated protein 1; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP rapamycin associated protein; FKBP12 rapamycin complex associated protein; FKBP12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; FLJ44809; FRAP; FRAP1; FRAP2; Mammalian target of rapamycin; Mechanistic target of rapamycin; mTOR; MTOR_HUMAN; OTTHUMP00000001983; RAFT1; Rapamycin and FKBP12 target 1; Rapamycin associated protein FRAP2; Rapamycin target protein 1; Rapamycin target protein; RAPT1; Serine/threonine-protein kinase mTOR;

Applications:

WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Reactivity:

Human, Mouse, Rat, Fish

Predicted Reactivity:

Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(100%)

Source:

Rabbit

Clonality:

Polyclonal

Purification:

The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.

Specificity:

Phospho-mTOR (Ser2448) Antibody detects endogenous levels of mTOR only when phosphorylated at Serine 2448.

Format:

Liquid

Concentration:

1mg/ml

Storage Condition and Buffer:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.

文献：

Reference Citations:

1). Ji J et al. Antagonizing peroxisome proliferator-activated receptor γ facilitates M1-to-M2 shift of microglia by enhancing autophagy via the LKB1-AMPK signaling pathway. Aging Cell 2018 May 8:e12774 (PubMed: 29740932) [IF=7.627]

2). Liang L et al. Autophagy inhibition potentiates the anti-angiogenic property of multikinase inhibitor through JAK2/STAT3/VEGFA signaling in non-small cell lung cancer cells. J Exp Clin Cancer Res 2019 Feb 12;38(1):71 (PubMed: 30755242) [IF=6.217]

3). He Y et al. Quercetin induces autophagy via FOXO1-dependent pathways and autophagy suppression enhances quercetin-induced apoptosis in PASMCs in hypoxia. Free Radic Biol Med 2017 Feb;103:165-176 (PubMed: 27979659) [IF=6.020]

Application: WB Species:rat; Sample:Not available

4). Jin J et al. Rapamycin Reduces Podocyte Apoptosis and is Involved in Autophagy and mTOR/ P70S6K/4EBP1 Signaling. Cell Physiol Biochem 2018;48(2):765-772 (PubMed: 30025409) [IF=5.500]

5). Li M et al. Respiratory Syncytial Virus Replication Is Promoted by Autophagy-Mediated Inhibition of Apoptosis. J Virol 2018 Mar 28;92(8) (PubMed: 29386287)

6). Li M et al. Respiratory Syncytial Virus Replication Is Promoted by Autophagy-Mediated Inhibition of Apoptosis. J Virol 2018 Mar 28;92(8) (PubMed: 29386287)

7). Wu D et al. Olaquindox disrupts tight junction integrity and cytoskeleton architecture in mouse Sertoli cells. Oncotarget 2017 Aug 16;8(51):88630-88644 (PubMed: 29179463)

8). Wang KZ et al. Dietary gossypol reduced intestinal immunity and aggravated inflammation in on-growing grass carp (Ctenopharyngodon idella). Fish Shellfish Immunol 2018 Dec 10 (PubMed: 30543935)

9). et al. Strontium promotes osteogenic differentiation by activating autophagy via the the AMPK/mTOR signaling pathway in MC3T3‑E1 cells.

10). Xue TF et al. PD149163 induces hypothermia to protect against brain injury in acute cerebral ischemic rats. J Pharmacol Sci 2017 Nov;135(3):105-113 (PubMed: 29113791)

11). Wu Z et al. Traditional Chinese Medicine CFF-1 induced cell growth inhibition, autophagy, and apoptosis via inhibiting EGFR-related pathways in prostate cancer. Cancer Med 2018 Apr;7(4):1546-1559 (PubMed: 29533017)

12). Jiang QQ et al. miR-25 Promotes Melanoma Progression by regulating RNA binding motif protein 47. Med Sci (Paris) 2018 Oct;34 Focus issue F1:59-65 (PubMed: 30403177)

13). Song Y et al. AMPK activation-dependent autophagy compromises oleanolic acid-induced cytotoxicity in human bladder cancer cells. Oncotarget 2017 Jul 4;8(40):67942-67954 (PubMed: 28978086)

Application: WB Species:human; Sample:Not available

14). Huang L et al. Neuroprotective Effect of Curcumin Against Cerebral Ischemia-Reperfusion Via Mediating Autophagy and Inflammation. J Mol Neurosci 2018 Jan;64(1):129-139 (PubMed: 29243061)

15). Li XG et al. Neuroprotective effects of rapamycin on spinal cord injury in rats by increasing autophagy and Akt signaling. Neural Regen Res 2019 Apr;14(4):721-727 (PubMed: 30632514)

16). Zheng L et al. Selenium deficiency impaired immune function of the immune organs in young grass carp (Ctenopharyngodon idella). Fish Shellfish Immunol 2018 Jun;77:53-70 (PubMed: 29559270)

17). Wu Z et al. EGFR‑associated pathways involved in traditional Chinese medicine (TCM)‑1‑induced cell growth inhibition, autophagy and apoptosis in prostate cancer. Mol Med Rep 2018 Jun;17(6):7875-7885 (PubMed: 29620175)

18). Hu J et al. Ursodeoxycholic acid ameliorates hepatic lipid metabolism in LO2 cells by regulating the AKT/mTOR/SREBP-1 signaling pathway. World J Gastroenterol 2019 Mar 28;25(12):1492-1501 (PubMed: 30948912)

19). Zhao ZH et al. PirB Overexpression Exacerbates Neuronal Apoptosis by Inhibiting TrkB and mTOR Phosphorylation After Oxygen and Glucose Deprivation Injury. Cell Mol Neurobiol 2017 May;37(4):707-715 (PubMed: 27443384)