文献支持人硬骨素(SOST)酶联免疫试剂盒Human Sclerostin(SOST) ELISA Kit【华美生物】

库存 ：500

供应商 ：武汉华美生物工程有限公司

检测限 ：31.25 pg/mL-2000 pg/mL

检测方法 ：Sandwich

应用 ：ELISA

适应物种 ：Homo sapiens (Human)

样本 ：serum, plasma, tissue homogenates

规格 ：96T/48T

The human Sclerostin (SOST) ELISA Kit is engineered for accurate measurement of human SOST levels from samples including serum, plasma, or tissue homogenates. It uses the Sandwich-ELISA mechanism in combination with the enzyme-substrate chromogenic reaction to measure the SOST content in the sample. The color intensity is positively correlated with SOST content in the sample. The SOST concentration can be calculated according to the standard curve. This kit is tested with high sensitivity, strong specificity, good linearity, high precision and recovery, as well as lot-to-lot consistency.

SOST is expressed by osteocytes and articular chondrocytes. SOST binds to its receptors on the cell surface of osteoblasts, which suppresses Wnt/β-catenin signaling, thereby inhibiting osteoblast differentiation, proliferation, and activity, leading to reduced osteoblastic bone formation. SOST is essential for normal B lymphocyte development. The absence of SOST causes increased B cell apoptosis and reduced CXCL12, a critical B cell growth-stimulating factor. You et al. showed that SOST is necessary for inducing Th17 cell differentiation, which contributes to bone resorption, through promoting the levels of IL-6 and TFG-β that are related to Th17 differentiation.

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
							pg/ml OD1 OD2 Average Corrected 2000 1.932 1.904 1.918 1.808 1000 1.516 1.481 1.499 1.389 500 1.112 1.101 1.107 0.997 250 0.733 0.687 0.710 0.600 125 0.547 0.504 0.526 0.416 62.5 0.329 0.309 0.319 0.209 31.25 0.197 0.181 0.189 0.079 0 0.112 0.107 0.110