重组鼠VSTM3蛋白|重组鼠具有免疫球蛋白和 ITIM 结构域的 T 细胞免疫受体蛋白

保存条件 ：Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.

英文名 ：Mouse VSTM3 Protein, His Tag

库存 ：999

供应商 ：卡梅德生物科技（天津）有限公司

规格 ：10ug/50ug

产品编号: KMP2342产品名称: Mouse VSTM3 Protein, His Tag中文名称: 重组鼠VSTM3蛋白中文全称: 重组鼠具有免疫球蛋白和 ITIM 结构域的 T 细胞免疫受体蛋白关键词: 具有免疫球蛋白和 ITIM 结构域的 T 细胞免疫受体, T-cell immunoreceptor with Ig and ITIM domains,, VSIG9, VSTM3, TIGIT, V-set and transmembrane domain-containing protein 3, V-set and immunoglobulin domain-containing protein 9, Mouse VSTM3 Protein, His Tag, Recombinant Protein, KMP2342物种: Mouse宿主: HEK293 Cells规格: 50ug, 100ug, 200ug纯化方式: Affinity purification纯度: >95% as determined by SDS-PAGE内毒素水平: <1.0 EU/ug determined by the LAL method缓冲体系: PBS, pH7.4Uniprot: P86176SDS-PAGE: 功能: Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.产品背景: T cell immunoreceptor with Ig and ITIM domains(TIGIT), also called WUCAM, VSIG9 and Vstm3, is a member of the CD28 family within the Ig superfamily of proteins. TIGIT contains an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif(ITIM), and is expressed on regulatory, memory, activated T cells and NK cells. TIGIT binds to CD155(PVR) that appear on dendritic cells(DC), macrophages and endothelium with high affinity, and CD112(PVRL2) with lower affinity, but not CD113(PVRL3). TIGIT-Fc fusion protein could interact with PVR on DC and enhance the secretion of IL-10, but inhibit the macrophage activation. Mice lacking TIGIT show increased T cell responses and susceptibility to autoimmune challenges, while knockdown of TIGIT with siRNA in human memory T cells did not affect T cell responses.保存条件: Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.运输条件: In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.说明: This product is for research use only.官网链接: https://www.kmdbioscience.cn/参考文献: