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库存 ：大量
供应商 ：广州威佳科技有限公司
规格 ：100ul
产品概况
| 货号 | BM4853 |
|---|---|
| 产品名称 | Anti-GRM1 Antibody |
| 基因名 | GRM1 |
| 抗体来源 | Rabbit |
| 克隆 | Monoclonal |
| 抗体亚型 | Rabbit |
| 分子量 | 101KD |
| 免疫原 | A synthesized peptide derived from human mGluR1 |
| 内容 | 500 ug/ml;Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500 ug/ml |
| 产品形态 | Liquid |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied. 6 months 2 to 8℃ after reconstitution. Avoid repeated freezing and thawing. |
| 背景资料 | This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| 研究类别 | 1. Ganesh, S., Amano, K., Yamakawa, K. Assignment of the gene GRM1 coding for metabotropic glutamate receptor 1 to human chromosome band 6q24 by in situ hybridization. Cytogenet. Cell Genet. 88: 314-315, 2000.2. Ortiz, P., Vanaclocha, F., Lopez-Bran, E., Esquivias, J. I., Lopez-Estebaranz, J. L., Martin-Gonzalez, M., Arrue, I., Garcia-Romero, D., Ochoa, C., Gonzalez-Perez, A., Ruiz, A., Real, L. M. Genetic analysis of the GRM1 gene in human melanoma susceptibility. Europ. J. Hum. Genet. 15: 1176-1182, 2007.3. Sachs, A. J., Schwendinger, J. K., Yang, A. W., Haider, N. B., Nystuen, A. M. The mouse mutants recoil wobbler and nmf373 represent a series of Grm1 mutations. Mammalian Genome 18: 749-756, 2007. |
| Uniprot ID | GRM1: Q13255 |
产品应用细节
为了提供优质的抗体，博士德对每一批抗体都用没有转染过的细胞系和体细胞组织检测，以保证博士德出品的抗体有足够的亲和性足以和对应蛋白天然的表达含量起反应。
| 应用 | 稀释度* |
|---|---|
| Western blot(WB): | 1:500-2000 |
*稀释度需要用户自己调试，此处数据仅供参考。
**博士德提供高敏感的二抗和检测试剂盒。详情见相关产品推荐。
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[list_product_images]Western blot analysis of mGluR1 expression in Mouse brain lysate.[/list_product_images]
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入驻年限：11年
