Anti-KAT9/ELP3 Antibody(A02833-1-50ul)价格_品牌:BOSTER-丁香通官网

库存：大量

供应商：广州威佳科技有限公司

规格：50ul

产品概况

货号	A02833-1
产品名称	Anti-ELP3 Antibody
基因名	ELP3
抗体来源	Rabbit
克隆	Polyclonal
抗体亚型	Rabbit IgG
分子量	62KD
免疫原	A synthetic peptide corresponding to a sequence of human KAT9/ELP3 (RDPTKFQHQGFGMLLMEEAERIAREEH).
内容	500 ug/ml antibody with PBS ，0.02% NaN3 , 1 mg BSA and 50% glycerol.
纯化方式	Immunogen affinity purified.
浓度	500 ug/ml
产品形态	Liquid
保存条件	12 months from date of receipt，-20℃ as supplied. 6 months 2 to 8℃ after reconstitution. Avoid repeated freezing and thawing.
背景资料	Elongator complex protein 3, also named KAT9, is a protein that in humans is encoded by the ELP3 gene. It is mapped to 8p21.1. ELP3 is the catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. ELP3 supports the migration and branching of projection neurons through acetylation of alpha-tubulin in the developing°Cerebral cortex. In mammals, ELP3 is important for paternal DNA demethylation afterfertilization. ELP3 is potentially involved in cellular redox homeostasis by mediating the acetylation ofglucose-6-phosphate dehydrogenase. Besides, ELP3 may play a role in°Chromatin remodeling and is involved in acetylation of histones H3 and probably H4.
研究类别	1. Hawkes NA, Otero G, Winkler GS, Marshall N, Dahmus ME, Krappmann D, Scheidereit C, Thomas CL, Schiavo G, Erdjument-Bromage H, Tempst P, Svejstrup JQ (Jan 2002). "Purification and characterization of the human elongator complex". J Biol Chem. 277 (4): 3047–52.2. Creppe C, Malinouskaya L, Volvert ML, Gillard M, Close P, Malaise O, Laguesse S, Cornez I, Rahmouni S, Ormenese S, Belachew S, Malgrange B, Chapelle JP, Siebenlist U, Moonen G, Chariot A, Nguyen L (Feb 2009). "Elongator controls the migration and differentiation of cortical neurons through acetylation of alpha-tubulin".°Cell. 136 (3): 551–64.
Uniprot ID	ELP3: Q9H9T3
推荐配套的二抗和检测试剂	Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P). *Blocking peptide 可以联系我们购买。

产品应用细节

为了提供优质的抗体，博士德对每一批抗体都用没有转染过的细胞系和体细胞组织检测，以保证博士德出品的抗体有足够的亲和性足以和对应蛋白天然的表达含量起反应。

应用	稀释度*
Western blot(WB):	1:500-2000

*稀释度需要用户自己调试，此处数据仅供参考。

**博士德提供高敏感的二抗和检测试剂盒。详情见相关产品推荐。

产品图片描述

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[list_product_images]Figure 1. Western blot analysis of ELP3 using anti-ELP3 antibody (A02833-1).

Lane 1: human placenta tissue lysates,
Lane 2: human K562 whole cell lysates,
Lane 3: human U2OS whole cell lysates,
Lane 4: human HepG2 whole cell lysates,
Lane 5: human A549 whole cell lysates,
Lane 6: human U-87MG whole cell lysates,
Lane 7: human Caco-2 whole cell lysates,
Lane 8: human Hela whole cell lysates.
anti-ELP3 antigen affinity purified polyclonal antibody (Catalog # A02833-1)probed with a goat anti-rabbit IgG-HRP secondary antibody The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) . A specific band was detected for ELP3 at approximately 62KD. The expected band size for ELP3 is at 62KD.|Figure 2. Western blot analysis of ELP3 using anti-ELP3 antibody (A02833-1).

Lane 1: mouse kidney tissue lysates,
Lane 2: mouse lung tissue lysates,
Lane 3: mouse NIH3T3 whole cell lysates.
anti-ELP3 antigen affinity purified polyclonal antibody (Catalog # A02833-1)probed with a goat anti-rabbit IgG-HRP secondary antibody The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) . A specific band was detected for ELP3 at approximately 62KD. The expected band size for ELP3 is at 62KD.[/list_product_images]