文献支持GRM2 Polyclonal Antibody_货号:E-AB-19414_多克隆抗体
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抗体名 :GRM2 Polyclonal Antibody_货号:E-AB-19414_多克隆抗体
抗体英文名 :GRM2 Polyclonal Antibody
应用范围 :IHC;ELISA
宿主 :Rabbit
适应物种 :Human; Mouse; Rat
保质期 :12个月
目录编号 :E-AB-19414
级别 :科研级别
库存 :999
供应商 :武汉伊莱瑞特生物科技股份有限公司
标记物 :Unconjugated
克隆性 :Polyclonal
保存条件 :Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
形态 :液体
亚型 :IgG
规格 :200μL/120μL/60μL/20μL
产品名称:GRM2 Polyclonal Antibody货号:E-AB-19414
Verified Samples |
Verified Samples in IHC:Human tonsil
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Dilution |
IHC 1:50-1:300, ELISA 1:5000-1:10000
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Clonality |
Polyclonal
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Isotype |
IgG
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Immunogen |
Synthetic peptide of human GRM2
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Abbre |
GRM2
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Synonyms |
AMPA selective glutamate receptor 2 ;GLUR2;GLURB;Glutamate metabotropic receptor 2;Glutamate receptor homolog;Glutamate receptor metabotropic 2;GPRC1B;GRM2;GRM2;Metabotropic glutamate receptor 2;mGlu2;mGluR2;OTTHUMP00000210984;OTTHUMP00000210986抗体
|
Swissprot |
Q14416
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Cellular Localization |
Cell membrane.
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Concentration |
1.5 mg/mL
|
Storage |
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
|
Buffer |
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
|
Purification Method |
Antigen affinity purification
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Research Areas |
Neuroscience
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Conjugation |
Unconjugated
|
Background |
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene.
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