文献支持Claudin 1 Polyclonal Antibody_货号:E-AB-12455_多克隆抗体

Verified Samples in WB:Hela
Verified Samples in IHC:Human esophagus cancer,Human cervical cancer

WB 1:1000-1:3000, IHC 1:100-1:300

Polyclonal

IgG

Synthetic peptide of human CLDN1

CLDN1

Claudin-1;Claudin1;CLD 1;CLD1;CLD1;CLDN 1;Cldn1;ILVASC;SEMP 1;SEMP1;Senescence associated epithelial membrane protein 1;Senescence associated epithelial membrane protein;Senescence-associated epithelial membrane protein抗体

O95832

23kDa

Cell junction, tight junction. Cell membrane.

0.5 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Affinity purification

Cancer; Signal Transduction

Unconjugated

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.