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EM-163

CAS No. : 1206480-93-4

MCE 国际站：EM-163

产品活性：EM-163 是一种合成的 BB-Loop 模拟物。EM-163 可以通过靶向 MyD88 的 TIR 结构域，缓解炎症并防止中毒性休克导致的死亡。EM-163 可以用于 SEB 中毒的研究 (SEB: 葡萄球菌肠毒素 B)。

研究领域：Apoptosis  |  Immunology/Inflammation

作用靶点：TNF Receptor  |  IFNAR

In Vitro: EM-163 (50-100 μg/mL) can target the TIR domain, binding to the protein of the TIR domain and inhibit the interaction of the TIR-TIR domain .
EM-163 (10-500 μM; 30 min) inhibits the production of TNF-α, IFN-γ, IL-2 and IL-1b induced by SEB (200 ng/mL) in human mononuclear cells (MNS) .

In Vivo: EM-163 (0.21-0.86 mg/mouse; i.p.; Single dose) can effectively inhibit the release of proinflammatory cytokines and delay or avoid death from toxic shock caused by Staphylococcal enterotoxin B (SEB) in BALB/c mice.

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