Empire Genomics - CCND1-IGH-Split-20-ORGR - CCND1/IGH Split Fusion FISH Probe

Name：CCND1/IGH Split Fusion FISH Probe

SKU：CCND1-IGH-Split-20-ORGR  20 (40 μL)

SKU：CCND1-IGH-Split-20-GOGR  20 (40 μL)

SKU：CCND1-IGH-Split-20-REGR   20 (40 μL)

Brand：Empire Genomics

 

Our CCND1/IGH split probe is designed to detect fusions between CCND1 and IGH. To account for
the high degree of cross homology in the region containing IGH, part of the IGH portion has been
removed. The probe comes labeled in orange and green, but can be customized to meet your
needs.

Gene Background: CCND1-IGH fusion is generated by t(11;14)(q13.3;q32.3), which places CCND1
gene next to IGH, resulting in constitutive overexpression of CCND1. The fusion can be found in
up to 95% of patients with mantle cell lymphomas (MCL), and is considered the genetic hallmark
of this subtype of low-grade peripheral B-cell neoplasms. CCND1-IGH has also been identified in
other lymphoproliferative disorders (LPDs), such as B-prolymphocytic leukemia (BLL), and, less
frequently, in plasma cell myelomas and B-cell chronic lymphocytic leukemia (CLL).

 

 

Product Details

 

SKU                                                                        Test Kits             Buffer                 

CCND1-IGH-Split-20-ORGR  (Standard Design)    20 (40 μL)         200 μL

CCND1-IGH-Split-20-GOGR                                   20 (40 μL)          200 μL

CCND1-IGH-Split-20-REGR                                    20 (40 μL)          200 μL