文献支持Cyclin B1 抗体 [BCLB1-1]-Cyclin B1 Antibody [BCLB1-1]

免疫原 ：Recombinant human full-length protein was used as the immunogen for the Cyclin B1 antibody.

保存条件 ：Aliquot and Store at 2-8℃

保质期 ：1年

级别 ：科研级别

库存 ：100

供应商 ：艾美捷科技

宿主 ：小鼠

应用范围 ：IF, IHC-P

抗体英文名 ：Cyclin B1 Antibody [BCLB1-1]

抗体名 ：Cyclin B1 Antibody [BCLB1-1]

规格 ：100ug

Cyclin B1 抗体 [BCLB1-1]，Cyclin B1 Antibody [BCLB1-1]，Cyclin B1 抗体 [BCLB1-1],Cyclin B1 Antibody [BCLB1-1]

产品名称：Cyclin B1 抗体 [BCLB1-1]-Cyclin B1 Antibody [BCLB1-1]

产品货号：PSI-33-993-100ug

产品规格：100ug

背景资料：Cyclin B1 (CCNB1) is a regulatory protein involved in mitosis. The gene product complexes with p34 (Cdk1) to form the maturation-promoting factor (MPF). Cyclin B1 contributes to the switch-like all or none behavior of the cell in deciding to commit to mitosis. Its activation is well-regulated, and positive feedback loops ensure that once the CCNB1-Cdk1 complex is activated, it is not deactivated. CCNB1-Cdk1 is involved in the early events of mitosis, such as chromosome condensation, nuclear envelope breakdown, and spindle pole assembly. Once activated, CCNB1-Cdk1 promotes several of the events of early mitosis. The active complex phosphorylates and activates 13S condensin, which helps to condense chromosomes. Another important function of the complex is to break down the nuclear envelope. The nuclear envelope is a membranous structure containing large protein complexes supported by a network of nuclear lamins. Phosphorylation of the lamins by CCBN1-Cdk1 causes them to dissociate, compromising the structural integrity of the nuclear envelope so that it breaks down. The destruction of the nuclear envelope is important because it allows the mitotic spindle to access the chromosomes. [Wiki]

保存建议：Cyclin B1 抗体 [BCLB1-1]-Cyclin B1 Antibody [BCLB1-1]Aliquot and Store at 2-8℃

应用类型：IF, IHC-P

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