文献支持HA721864·Anti-Phospho-PKA alpha/beta/gamma (catalytic subunit) (T197) Antibody [JE45-17]

靶点 ：PKA alpha/beta/gamma (catalytic subunit)

浓度 ：1 mg/mL.

应用范围 ：WB

适应物种 ：Human,Mouse,Rat

保质期 ：1年

供应商 ：Huabio

标记物 ：Non-conjugated

保存条件 ：Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.

形态 ：Liquid

亚型 ：IgG

免疫原 ：Synthetic phosphopeptide corresponding to residues surrounding Thr197 of PKA C.

规格 ：50μl/100μl

The catalytic subunit α of protein kinase A is a key regulatory enzyme that in humans is encoded by the PRKACA gene. cAMP-dependent protein kinase catalytic subunit beta is an enzyme that in humans is encoded by the PRKACB gene. cAMP-dependent protein kinase catalytic subunit gamma is an enzyme that in humans is encoded by the PRKACG gene. cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the protein kinase A (PKA), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of PKA is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of PKA have been identified in humans. Defective regulation of PKA holoenzyme activity has been linked to the progression of cardiovascular disease, certain endocrine disorders and cancers.