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靶点 :CARD9
浓度 :1 mg/mL.
应用范围 :WB,IF-Cell,FC
适应物种 :Human,Mouse,Rat
保质期 :1年
供应商 :Huabio
标记物 :Non-conjugated
保存条件 :Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
形态 :Liquid
亚型 :IgG
免疫原 :Recombinant protein within human CARD9 aa 1-200 / 536.
规格 :50μl/100μl
Caspase recruitment domain-containing protein 9 is an adaptor protein of the CARD-CC protein family, which in humans is encoded by the CARD9 gene. It mediates signals from pattern recognition receptors to activate pro-inflammatory and anti-inflammatory cytokines, regulating inflammation. Homozygous mutations in CARD9 are associated with defective innate immunity against yeasts, like Candida and dermatophytes. CARD9 is a member of the CARD protein family, which is defined by the presence of a characteristic caspase-associated recruitment domain (CARD). This protein was identified by its selective association with the CARD domain of BCL10, a positive regulator and NF-κB activation. It is thought to function as a molecular scaffold for the assembly of a BCL10 signaling complex that activates NF-κB. Several alternatively spliced transcript variants have been observed, but their full-length nature is not clearly defined.杭州华安生物技术有限公司
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入驻年限:7年