文献支持抗 GATA3 荧光标记APC 抗体

供应商 ：齐源

库存 ：999

靶点 ：GATA3

级别 ：GATA3 Antibody

目录编号 ：GATA3 Antibody

克隆性 ：单克隆

抗原来源 ：小鼠

保质期 ：GATA3 Antibody

抗体英文名 ：anti-GATA3 Antibody-APC

抗体名 ：GATA3 Antibody

标记物 ：GATA3 Antibody

宿主 ：小鼠

适应物种 ：人、小鼠

免疫原 ：GATA3 Antibody

亚型 ：GATA3 Antibody

形态 ：GATA3 Antibody

应用范围 ：ICFC

保存条件 ：2-8℃

浓度 ：GATA3 Antibody

规格 ：25 tests/100 tests

anti-GATA3 Antibody-APC详细如下：

Description ：GATA3 functions as a major regulator of T helper 2 (Th2) cell differentiation in immune cells.GATA3 expression is upregulated through IL-4 receptor signaling or the Notch-mediatedpathway, which results in production of IL-4, IL-5, and IL-13 cytokines, responsible forpreferential differentiation of Th2-cells. GATA3 has been shown to regulate earlydevelopmental processes of T cells, such as T cell commitment, positive selection, and postcommitment CD4 T cell survival. In the mammary gland, GATA3 plays an important role indifferentiation and commitment of luminal epithelial cells. In a mouse model, exogenousexpression of GATA3 in undifferentiated breast carcinoma cells induces differentiation andsuppresses spreading of the tumor cells, suggesting that GATA3 is involved in preventingmalignancy of breast cancer. GATA3 has been reported to be essential in the development ofa variety of normal tissues. Defect in GATA3 results in hypoparathyroidism, sensorineuraldeafness, and renal dysplasia (HDR syndrome).

Verified Reactivity ：Human, Mouse

Antibody Type ：Monoclonal

Host Species ：Mouse

Immunogen ：Partial human GATA3 recombinant protein (1-258 aa).

Formulation ：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)

Preparation ：The antibody was purified by affinity chromatography and conjugated with APC under optimalconditions.

Concentration ：Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysis online tool.)

Storage & Handling ：The antibody solution should be stored undiluted between 2°C and 8°C, and protected fromprolonged exposure to light. Do not freeze.

Application ：ICFC - Quality tested

Recommended Usage ：Each lot of this antibody is quality control tested by intracellular immunofluorescent staining withflow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl permillion cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser ：Red Laser (633 nm)