BioLegend 936904 PE anti-STAT5 Phospho (Tyr694)

库存 ：99

英文名 ：BioLegend 936904 PE anti-STAT5 Phospho (Tyr694)

供应商 ：北京云肽生物科技有限公司

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BioLegend 936904 PE anti-STAT5 Phospho (Tyr694)
产品简介：
产品品牌：BioLegend
产品货号：936904
产品名称：BioLegend 936904 PE anti-STAT5 Phospho (Tyr694)
产品规格：100 tests

产品说明：
Clone   A17016B.Rec (See other available formats)
Regulatory Status   RUO
Other Names
Signal transducer and activator of transcription 5A
Isotype   Mouse IgG1, κ

描述
STAT5是信号转导子和转录因子激活子（STAT）家族的成员，介导生长和细胞因子信号传导。STAT5由两个密切相关的家族成员STAT5A和STAT5B组成，它们具有96%的序列同源性，并且在功能上是冗余的。激活后，STAT5被受体酪氨酸激酶磷酸化，进而通过其SH2结构域与其他家族成员形成同源二聚体或同源二聚物。二聚化的STAT5易位到细胞核并结合STAT5反应元件（TTCXXXGAA）。STAT5在细胞增殖、抗凋亡、早期B细胞分化和T细胞发育中起着至关重要的调节作用。
STAT5 is a member of the signal transducer and activator of transcription factors (STAT) family, mediating growth and cytokine signaling. STAT5 consists of two closely related family members, STAT5A and STAT5B, which exhibit 96% sequence homology and are functionally redundant. Upon activation, STAT5 is phosphorylated by receptor tyrosine kinases and, in turn, forms homodimers or hererodimers with other family members through its SH2 domains. The dimerized STAT5 translocates to the nucleus and binds to the STAT5 response element (TTCXXXGAA). STAT5 plays crucial regulatory roles in cell proliferation, anti-apoptosis, early B cell differentiation, and T cell development.

Product Details
Isotype Control    PE Mouse IgG1, κ Isotype Ctrl (ICFC)
Verified Reactivity    Human
Antibody Type    Recombinant
Host Species    Mouse
Immunogen
Peptide from Human Stat5A phosphorylated at Tyr694
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)

Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.

Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)

Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application    ICFC - Quality tested

Recommended Usage
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Antigen Details
Structure
794 amino acids, predicted molecular weight of 91 kD; contains a SH2 domains responsible for homodimerization or heterodimerization.

Distribution
Cytoplasm; phosphorylated form translocates to the nucleus.

Function
STAT5 is a transcription regulator and is involved in cell differentiation, proliferation, and survival, in response to several cytokines, such as interleukins, erythropoietin, growth hormone, thrombopoietin, and prolactin.

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