BioLegend 834502 Purified anti-FOX3 (NeuN)

库存 ：99

英文名 ： Purified anti-FOX3 (NeuN)

供应商 ：北京云肽生物科技有限公司

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BioLegend 834502 Purified anti-FOX3 (NeuN)
产品简介：
产品品牌：BioLegend
产品货号：834502
产品名称：BioLegend 834502 Purified anti-FOX3 (NeuN)
产品规格：25 µL

产品说明：
Clone   1B7 (See other available formats)
Regulatory Status   RUO
Other Names
RNA binding protein fox-1 homolog 3, fox-1 homolog C, neuronal nuclei, hexaribonucleotide binding protein 3
Previously   Covance Catalog# SIG-39860
Isotype   Mouse IgG2b, κ

描述
Fox3是一个由3个哺乳动物Fox同源物组成的家族之一。Fox是在秀丽隐杆线虫中发现的一种与性别决定有关的基因，Fox这个名字是“X上的女性化位点”的缩写。Fox蛋白及其3种哺乳动物同源物均为约46kD的蛋白，每种蛋白都包括一个高度保守的RRM型RNA识别基序，该基序对应于一个由4条β链和两条α螺旋组成的约70个氨基酸的小结构。Fox3是一种具有RNA剪接功能的蛋白质，在神经元细胞核中大量特异性表达。1B7抗体显示Fox3/NeuN的强细胞核和远端细胞质染色，星形胶质细胞和其他类型的非神经元细胞完全没有染色。因此，这种Fox3/NeuN抗体是神经元细胞的优秀标志物。
Fox3 is one of a family of 3 mammalian Fox homologues. Fox was discovered in C. elegans as a gene involved in sex determination, and the name Fox is an acronym of "Feminizing locus on X". The Fox protein and its 3 mammalian homologues are all about 46 kD proteins, each of which includes a central highly conserved RRM type RNA recognition motif, which corresponds to a small ~70 amino acid structure consisting of 4 beta strands and two alpha-helices. Fox3 is a protein which has a function in RNA splicing and is expressed heavily and specifically in neuronal nuclei. The 1B7 antibody reveals strong nuclear and distal cytoplasmic staining for Fox3/NeuN and the complete absence of staining of astrocytes and other kinds of non-neuronal cells. This Fox3/NeuN antibody is therefore an excellent marker of neuronal cells.

Product Details
Isotype Control   Purified Mouse IgG2b, κ Isotype Ctrl
Verified Reactivity   Human, Mouse, Rat
Antibody Type   Monoclonal
Host Species   Mouse
Immunogen
Antibody was raised against the N-terminal 100 amino acids of human Fox3 as expressed in and purified from E. coli.

Formulation    Phosphate-buffered solution + 10mM sodium azide.
Preparation   The antibody was purified by affinity chromatography.
Concentration    1 mg/mL

Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.
Application    IHC-P -  Quality tested
WB, ICFC - Verified
ICC, IHC-F - Reported in the literature, not verified in house

Recommended Usage
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 0.5 - 1.0 µg/mL is suggested. For western blotting, the suggested use of this reagent is 0.01 - 0.05 µg/mL. For intracellular flow cytometric staining, the suggested use of this reagent is ≤ 0.125 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Antigen Details
Structure   Expected MW: 46 kD and 48 kD
Cell Type    Mature Neurons, Neural Stem Cells
Biology Area
Cell Biology, Neuroscience, Neuroscience Cell Markers, Stem Cells
Molecular Family    Nuclear Markers

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