BioLegend 803015 Anti-β-Amyloid, 1-16

库存 ：99

英文名 ： Anti-β-Amyloid, 1-16

供应商 ：北京云肽生物科技有限公司

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BioLegend 803015 Anti-β-Amyloid, 1-16
产品简介：
产品品牌：BioLegend
产品货号：803015
产品名称：BioLegend 803015 Anti-β-Amyloid, 1-16
产品规格：200 µL

产品说明：
Clone   6E10 (See other available formats)
Regulatory Status   RUO
Other Names
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, Amyloid beta A4 protein, preA4, protease, peptidase nexin-II, beta-amyloid peptide, alzheimer disease amyloid protein, cerebral vascular amyloid peptide, APP, Amyloid Precursor Protein

Previously     Signet Catalog# 9300-02
Signet Catalog# 9300-05
Signet Catalog# 9300-10
Covance Catalog# SIG-39300
Isotype   Mouse IgG1, κ

描述
阿尔茨海默病的特征是聚集的Aβ肽在老年斑块和血管沉积物中积聚。Aβ肽来源于淀粉样蛋白前体蛋白（APP），通过β-分泌酶和γ-分泌酶对APP的顺序蛋白水解切割产生不同的Aβ种类。β可以聚集形成可溶性寡聚物和不溶性原纤维或无定形组装体。某些形式的聚集肽对神经元是有毒的。
Alzheimer's disease is characterized by the accumulation of aggregated Aβ peptides in senile plaques and vascular deposits. Aβ peptides are derived from amyloid precursor proteins (APP) through sequential proteolytic cleavage of APP by β-secretases and γ-secretases generating diverse Aβ species. Aβ can aggregate to form soluble oligomeric species and insoluble fibrillar or amorphous assemblies. Some forms of the aggregated peptides are toxic to neurons.

Product Details
Verified Reactivity   Human
Antibody Type   Monoclonal
Host Species   Mouse
Preparation   Ascites
Concentration
The concentration is not quantified as this product is sold as undiluted crude mouse ascites fluid. The concentration might vary from lot-to-lot and an estimated concentration would be 1-3 mg/ml.

Storage & Handling
Store at -20°C or below. Upon initial thawing, apportion into working aliquots and store at -20°C or below. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody. Do not store in frost-free freezers.
Application     WB - Quality tested
Direct ELISA, IHC-P – Verified
IHC-F, EM - Reported in the literature, not verified in house

Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested dilution of this reagent is 1:1,000 to 1:20,000. For Direct ELISA, the suggested dilution of this reagent is 1:10,000 to 1:100,000. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, the suggested dilution of this reagent is 1:1,000 to 1:20,000. It is recommended that the reagent be titrated for optimal performance for each application.

Antigen Details
Structure
Amyloid precursor protein is a 770 amino acid protein with a molecular mass of ~100 kD. According to the UniProtKB database, APP (ID# P05067) has 11 isoforms (34 to ~90 kD) and the 770 form has been designated as the canonical form. Isoform APP695 is the predominant form expressed in neuronal tissue. Isoforms APP751 and APP770 are widely expressed in non-neuronal cells. Isoform APP751 is the most abundant form in T-lymphocytes. Aβ denotes peptides of 36-43 amino acids generated from cleavage of APP by secretases. Aβ has an apparent molecular mass of about 4 kD.

Distribution
Tissue distribution: Primarily nervous system, but also adipose tissue, intestine, muscle.
Cellular distribution: Cytosol, endosomes, nucleus, plasma membrane, extracellular, and golgi apparatus.

Function
The normal function of Aβ is not well understood. Several potential physiological roles have been proposed, including: activation of kinase enzymes; protection against oxidative stress; regulation of cholesterol transport; transcription factor, and as an anti-microbial agent.

Biology Area
Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation
Molecular Family   APP/β-Amyloid

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