BioLegend 615702 Purified anti-TCF1 (TCF7)

库存 ：99

英文名 ：BioLegend 615702 Purified anti-TCF1 (TCF7)

供应商 ：北京云肽生物科技有限公司

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BioLegend 615702 Purified anti-TCF1 (TCF7)
产品简介：BioLegend
产品货号：615702
产品名称：BioLegend 615702 Purified anti-TCF1 (TCF7)
产品规格：100 µg

产品说明：
Clone   W16175A (See other available formats)
Regulatory Status   RUO
Other Names
Transcription Factor 7, Transcription Factor 7 (T-Cell Specific, HMG-Box), T-Cell-Specific Transcription Factor 1, T-Cell Factor-7, T-Cell Factor 1, TCF1
Isotype   Rat IgG2a, κ

描述
TCF1是T细胞特异性转录因子家族中第一个被鉴定的成员。它在T细胞的发育和分化中起着重要作用。TCF1通过与转录抑制因子TLE蛋白结合而失活。在Wnt信号传导过程中，转录共激活因子CTNNB1积累，进而取代与TCF1相关的转录抑制因子。与CTNNB1的相互作用导致TCF1靶基因的反式激活。TCF1的缺失导致双阳性胸腺细胞大量凋亡，这表明TCF1是T细胞发育过程中胸腺细胞存活所必需的。除了在胸腺中的功能外，TCF1还通过GATA3的转录激活促进T细胞向外周Th2细胞分化。
TCF1 is the first identified member of the T-cell-specific transcription factor family.  It plays an important role in T cell development and differentiation. TCF1 is inactivated by association with the transcriptional repressor TLE proteins. During Wnt signaling, the transcriptional coactivator CTNNB1 accumulates and, in turn, replaces the transcriptional repressor associated with TCF1. Interaction with CTNNB1 results in transactivation of TCF1 target genes. Deletion of TCF1 causes massive apoptosis of double positive thymocytes, suggesting that TCF1 is required for thymocyte survival during T cell development. In addition to its function in the thymus, TCF1 promotes T cell differentiation to Th2 cells in the periphery through transcriptional activation of GATA3.

Product Details
Isotype Control   Purified Rat IgG2a, κ Isotype Ctrl
Verified Reactivity   Human, Mouse
Antibody Type   Monoclonal
Host Species   Rat
Immunogen
Partical recombinant mouse TCF1 corresponding to amino acid residues 54-303

Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation
The antibody was purified by affinity chromatography.
Concentration   0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application   WB - Quality tested
IP - Verified

Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.25 - 1.0 µg per ml. For immunoprecipitation, the suggested use of this reagent is 2.5 µg per IP. It is recommended that the reagent be titrated for optimal performance for each application.

Antigen Details
Structure
TCF1 is a 384 amino acid protein with a predicted molecular weight of 42 kD.
Distribution   Tregs/nuclear distribution

Function
TCF1 is a transcription factor, involved in the canonical Wingless/Integration 1 (Wnt) signaling pathway. TCF1 is essential for survival of CD4/CD8 double positive thymocytes and differentiation of T cells in the periphery. ++
Cell Type   T cells
Biology Area   Transcription Factors

以下是 BioLegend 品牌部分产品，如需其他产品请联系本公司销售。
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BioLegend 400521 PE/Cyanine7 Rat IgG2a, κ Isotype Ctrl    RTK2758    25 ug
BioLegend 400522 PE/Cyanine7 Rat IgG2a, κ Isotype Ctrl    RTK2758    100 ug
BioLegend 400523 APC/Cyanine7 Rat IgG2a, κ Isotype Ctrl RTK2758    25 ug
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BioLegend 400527 Pacific Blue™ Rat IgG2a, κ Isotype Ctrl    RTK2758    100 ug
BioLegend 400529 PerCP Rat IgG2a, κ Isotype Ctrl   RTK2758    25 ug
BioLegend 400531 PerCP/Cyanine5.5 Rat IgG2a, κ Isotype Ctrl  RTK2758    25 ug
BioLegend 400535 Brilliant Violet 421™ Rat IgG2a, κ Isotype Ctrl    RTK2758    125 uL
BioLegend 400536 Brilliant Violet 421™ Rat IgG2a, κ Isotype Ctrl    RTK2758    500 uL
BioLegend 400539 Brilliant Violet 605™ Rat IgG2a, κ Isotype Ctrl    RTK2758    125 uL