BioLegend 339503 FITC anti-human CD158 (KIR2DL1/S1/S3/S5)

库存 ：99

英文名 ：FITC anti-human CD158 (KIR2DL1/S1/S3/S5)

供应商 ：北京云肽生物科技有限公司

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BioLegend 339503 FITC anti-human CD158 (KIR2DL1/S1/S3/S5)
产品简介：
产品品牌：BioLegend
产品货号：339503
产品名称：BioLegend 339503 FITC anti-human CD158 (KIR2DL1/S1/S3/S5)
产品规格：25 tests

产品说明：
Clone  HP-MA4 (See other available formats)
Regulatory Status  RUO
Other Names
CD158a, CD158g, CD158h, KIR2DL1, KIR2DS1, KIR2DS3, KIR2DS5
Isotype  Mouse IgG2b, κ

描述
CD158分子，也称为KIR（杀伤细胞免疫球蛋白样受体），是具有两个（KIR2D）或三个（KIR3D）Ig样细胞外结构域的跨膜蛋白家族。一些具有长细胞质结构域的KIRs含有ITIMs并具有抑制功能，而其他具有短细胞质区域的KIRs缺乏ITIM并具有激活功能。在人类中已有14个多态性KIR基因的报道。CD158主要在NK细胞亚群和少量CD8 + T细胞上表达。HLA-C是CD158a/h的配体。
CD158 molecules, also known as KIRs (killer cell immunoglobulin-like receptors), are a family of transmembrane proteins with either two (KIR2D) or three (KIR3D) Ig-like extracellular domains. Some KIRs with long cytoplasmic domains contain ITIMs and posses inhibitory functions and others with short cytoplasmic region lack ITIM and have activation functions. 14 polymorphic KIR genes have been reported in humans. CD158 is mainly expressed on a subset of NK cells and a small population of CD8+ T cells. HLA-C is the ligand of CD158a/h.

Product Details
Isotype Control  FITC Mouse IgG2b, κ Isotype Ctrl
Verified Reactivity  Human
Reported Reactivity  Baboon, Cynomolgus
Antibody Type  Monoclonal
Host Species  Mouse
Immunogen  Human NK cell clone LB2
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.

Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application  FC - Quality tested

Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser  Blue Laser (488 nm)
Application Notes
mAb HP-MA4 reacts with KIR2DL1 (CD158a), KIR2DS1 (CD158h), KIR2DS3, and KIR2DS5 (CD158g).

Additional reported applications include: inhibits NK cell mediated cytotoxicity and immunoprecipitation.

This clone has been tested in-house and determined to not be suitable for applications in immunohistochemistry of paraffin-embedded tissue sections (IHC-P).

Antigen Details
Structure
Contains two Ig-like extracellular domains, 58/50 kD
Distribution
Subset of NK cells and a small subset of CD8+ T cells
Function
Inhibits NK cell function, play a role in self-tolerance.
Ligand/Receptor   HLA-C
Cell Type   NK cells, T cells
Biology Area   Immunology, Inhibitory Molecules
Molecular Family   CD Molecules

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