BioLegend 327401 Purified anti-human SUSD2

库存 ：99

英文名 ：Purified anti-human SUSD2

供应商 ：北京云肽生物科技有限公司

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BioLegend 327401 Purified anti-human SUSD2
产品简介：
产品品牌：BioLegend
产品货号：327401
产品名称：BioLegend 327401 Purified anti-human SUSD2
产品规格：25 µg

产品说明：
Clone  W5C5 (See other available formats)
Regulatory Status  RUO
Other Names
Mesenchymal Stem Cells (MSC), Sushi domain containing 2 (SUSD2)
Isotype  Mouse IgG1, κ

描述
W5C5抗体与SUSD2（含有寿司结构域2）反应，SUSD2由骨髓间充质干细胞、血管周围平滑肌细胞和一些肿瘤细胞系表达。SUSD2是最近鉴定的一种由820个氨基酸组成的I型跨膜蛋白，由一个包含生长抑素B（SMB）的大细胞外区、MUC4和其他蛋白质中的粘附相关结构域（AMOP）、von Willebrand因子（vWF）和F1c Sushi结构域组成。间充质干细胞最初被命名为骨髓基质细胞。它们是一组成年干细胞，具有强大的自我更新能力和分化为多种细胞类型的多能性，包括成骨细胞、软骨细胞、肌细胞、脂肪细胞、β-胰岛细胞和某些神经元细胞。MSCs存在于许多细胞和组织中，如骨髓、胎盘、脂肪组织、成人外周血、胎儿血、皮肤、肝脏和肺。MSCs除了具有组织修复的可塑性外，还表现出强大的免疫抑制活性，在支持造血方面发挥着重要作用。
The W5C5 antibody reacts with SUSD2 (sushi domain containing 2) which is expressed by bone marrow mesenchymal stem cells, vessel-surrounding smooth muscle cells, and a few neoplastic cell lines. SUSD2 is a recently identified type I transmembrane protein of 820 amino acids consisting of a large extracellular region containing a Somatomedin B (SMB), an Adhesion-associated domain in MUC4 and Other Proteins (AMOP), a von Willebrand factor (vWF), and a F1c Sushi domain. Mesenchymal stem cells (MSCs) were originally named bone marrow stromal cells. They are a population of adult stem cells with a large capacity for self-renewal and multipotency for differentiation into a variety of cell types including osteoblasts, chondrocytes, myocytes, adipocytes, β-pancreatic islets cells, and certain neuronal cells. MSCs reside in many cells and tissues, such as bone marrow, placenta, adipose tissue, adult peripheral blood, fetal blood, skin, liver, and lung. Besides their plasticity for tissue repair, MSCs also exhibit powerful immunosuppressive activity and play an important role in supporting hematopoiesis.

Product Details
Isotype Control  Purified Mouse IgG1, κ Isotype Ctrl
Verified Reactivity  Human
Reported Reactivity   African Green, Baboon, Cynomolgus
Antibody Type  Monoclonal
Host Species  Mouse
Immunogen   Retinoblastoma cell line (Weri-RB-1 cells).
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration   0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application   FC - Quality tested
ICC - Reported in the literature, not verified in house

Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes
Additional reported applications (for the relevant formats) include: immunofluorescence2.

Antigen Details
Distribution   Bone marrow mesenchymal stem cells
Cell Type   Mesenchymal cells, Mesenchymal Stem Cells
Biology Area   Immunology, Stem Cells

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