BioLegend 156519 APC/Fire™ 810 anti-mouse NK-1.1

库存 ：99

英文名 ：APC/Fire™ 810 anti-mouse NK-1.1

供应商 ：北京云肽生物科技有限公司

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BioLegend  156519  APC/Fire™ 810 anti-mouse NK-1.1
产品简介：
产品品牌：BioLegend
产品货号：156519
产品名称：BioLegend  156519  APC/Fire™ 810 anti-mouse NK-1.1
产品规格：25 µg

产品说明：
Clone  S17016D (See other available formats)
Regulatory Status  RUO
Other Names  NKR-P1C, NKR-P1B, Ly-55, CD161b, CD161c
Isotype  Mouse IgG2a, κ

描述
NK-1.1表面抗原，也称为CD161b/CD161c和Ly-55，由NKR-P1B/NKR-P1C基因编码。它在一些小鼠株的NK细胞和NK-T细胞上表达，包括C57BL/6、FVB/N和NZB，但不在AKR、BALB/c、CBA/J、C3H、DBA/1、DBA/2、NOD、SJL和129上表达。NKR-P1C抗原的表达与体外肿瘤细胞的裂解和体内骨髓移植物的排斥反应有关。NK-1.1也被证明在NK细胞活化、IFN-γ产生和细胞毒性颗粒释放中发挥作用。NK-1.1和DX5通常用作小鼠NK细胞标记物。
NK-1.1 surface antigen, also known as CD161b/CD161c and Ly-55, is encoded by the NKR-P1B/NKR-P1C gene. It is expressed on NK cells and NK-T cells in some mouse strains, including C57BL/6, FVB/N, and NZB, but not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129. Expression of NKR-P1C antigen has been correlated with lysis of tumor cells in vitro and rejection of bone marrow allografts in vivo. NK-1.1 has also been shown to play a role in NK cell activation, IFN-γ production, and cytotoxic granule release. NK-1.1 and DX5 are commonly used as mouse NK cell markers.

Product Details
Verified Reactivity  Mouse
Antibody Type  Monoclonal
Host Species  Mouse
Immunogen  Mouse NK1.1-transfectants
Formulation  Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with APC/Fire™ 810 under optimal conditions.
Concentration  0.2 mg/mL

Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application  FC - Quality tested

Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

* APC/Fire™ 810 has a maximum excitation of 650 nm and a maximum emission of 810 nm.

Excessive exposure to light, and commonly used fixation, permeabilization buffers can affect APC/Fire™ 810 fluorescence signal intensity and spread. Please keep conjugates protected from light exposure. For more information and representative data, visit our Fire Dyes page.Excitation LaserRed Laser (633 nm)

Application Notes
Clone S17016D cross-blocks anti-mouse NK1.1 clone PK136, and can stain for NK1.1 post-formaldehyde and methanol-based fixation based on in-house testing.

Antigen Details
Structure   NKR-P1 gene family
Distribution
NK and NK-T cells in the NK1.1 mouse strains (C57BL, FVB/N, NZB)

Function
NK cell activation, IFN-γ production, cytotoxic granule release
Cell Type  NK cells, NKT cells
Biology Area  Immunology, Innate Immunity

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