BioLegend 153708 APC anti-mouse CX3CR1 Recombinant

库存 ：99

英文名 ：APC anti-mouse CX3CR1 Recombinant

供应商 ：北京云肽生物科技有限公司

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BioLegend 153708 APC anti-mouse CX3CR1 Recombinant
产品简介：
产品品牌：BioLegend
产品货号：153708
产品名称：BioLegend 153708 APC anti-mouse CX3CR1 Recombinant
产品规格：100 µg

产品说明：
Clone  QA16A03 (See other available formats)
Regulatory Status  RUO
Other Names
Chemokine (C-X3-C motif) receptor 1, Fractalkine receptor, GPR13, CCRL1, CMKBRL1, CMKDR1, V28
Isotype  Mouse IgG1, κ

描述
CX3CR1是一种40kD的G蛋白偶联受体，具有七个跨膜区。CX3CR1由常驻和选择性激活的巨噬细胞（M2）、单核细胞亚群、树突状细胞（DC）、NK细胞、记忆T细胞亚群和肥大细胞表达。CX3CR1参与炎症过程中的细胞募集，并参与细胞粘附和血管外渗。它的配体是CX3CL1，也称为fractalkine或神经肌动蛋白。CX3CR1也是HIV1的辅助受体，该基因的变异导致对HIV的易感性增加。在大脑中，它由神经胶质细胞表达，神经胶质细胞与神经元表达的CX3CL1相互作用。
CX3CR1 is a 40 kD, G-protein coupled receptor, with seven transmembrane regions. CX3CR1 is expressed by resident and alternatively activated macrophages (M2), a subset of monocytes, dendritic cells (DCs), NK cells, a subset of memory T cells, and mast cells. CX3CR1 is involved in cell recruitment during inflammation and participates in cell adhesion and extravasation from blood vessels. Its ligand is CX3CL1, also known as fractalkine or neurotactin. CX3CR1 is also a coreceptor for HIV1 and variations in this gene leads to increased susceptibility to HIV. In the brain, it is expressed by glial cells, which interact with CX3CL1 expressed by neurons.

Product Details
Isotype Control  APC Mouse IgG1, κ Isotype Ctrl
Verified Reactivity  Mouse
Antibody Type  Recombinant
Host Species  Mouse
Immunogen  Mouse CX3CR1-transfected cells

Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration  0.2 mg/ml

Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application  FC - Quality tested

Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser  Red Laser (633 nm)

Application Notes
This recombinant antibody clone is derived from clone SA011F11.

Antigen Details
Structure  G-protein coupled receptor, 7 transmembrane regions, 40 kD.
Distribution
Resident and alternatively activated macrophages (M2), subset of monocytes, dendritic cells (DCs), natural killer cells (NK), subset of memory T cells, mast cells, glial cells, and astrocytes.

Function
Involved in cell recruitment during inflammation, participates in cell adhesion and extravasation from blood vessels, coreceptor for HIV1.
Ligand/Receptor  CX3CL1 (fractalkine, neurotactin).

Cell Type
Astrocytes, Dendritic cells, Macrophages, Mast cells, Microglia, Monocytes, NK cells, T cells

Biology Area
Cell Biology, Immunology, Neuroinflammation, Neuroscience, Neuroscience Cell Markers
Molecular Family  Cytokine/Chemokine Receptors, GPCR

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