BioLegend 147319 Brilliant Violet 421™ anti-mouse/human CD324 (E-Cadherin)

库存 ：99

英文名 ： Brilliant Violet 421™ anti-mouse/human CD324 (E-Cadherin)

供应商 ：北京云肽生物科技有限公司

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BioLegend 147319 Brilliant Violet 421™ anti-mouse/human CD324 (E-Cadherin)
产品简介：
产品品牌：BioLegend
产品货号：147319
产品名称：BioLegend 147319 Brilliant Violet 421™ anti-mouse/human CD324 (E-Cadherin)
产品规格：50 µg

产品说明：
Clone  DECMA-1 (See other available formats)
Regulatory Status  RUO
Other Names  E-Cadherin, Cadherin-1, CDH1, and UVO
Isotype  Rat IgG1, κ

描述
CD324，也称为E-钙粘蛋白、钙粘蛋白-1、CDH1和UVO，是钙粘蛋白超家族的一员。它是一种钙依赖性跨膜细胞-细胞粘附糖蛋白，由四个细胞外钙粘蛋白重复序列和一个高度保守的细胞质尾部区域组成。CD324广泛表达于结肠、子宫、肝脏、角质形成细胞、大脑、心脏、肌肉、肾脏和胰腺的上皮细胞以及红系细胞中。CD324作为一种细胞粘附分子发挥作用，参与发育、细菌发病机制和肿瘤侵袭。在细菌发病机制中，CD324的胞外结构域介导细菌与哺乳动物细胞的粘附，而胞质结构域是内化所必需的。CD324与αEβ7整合素结合以介导细胞粘附，还与许多细胞内蛋白相互作用，包括erbin、ezrin、胱天蛋白酶-3、胱天酶-8、β-连环蛋白、早老素1和酪蛋白激酶II，以及其他细胞外蛋白，包括EGF受体。
CD324, also known as E-cadherin, cadherin-1, CDH1, and UVO is a member of the cadherin superfamily. It is a calcium-dependent, transmembrane cell-cell adhesion glycoprotein composed of four extracellular cadherin repeats and a highly conserved cytoplasmic tail region. CD324 is widely expressed in epithelial cells in the colon, uterus, liver, keratinocytes, brain, heart, muscle, kidney, and pancreas as well as erythroid cells. CD324 functions as a cell adhesion molecule involved in development, bacterial pathogenesis, and tumor invasion. In bacterial pathogenesis, the ectodomain of CD324 mediates bacterial adhesion to mammalian cells, while the cytoplasmic domain is required for internalization. CD324 binds to the αEβ7 integrin to mediate cell adhesion and also interacts with a number of intracellular proteins including including erbin, ezrin, caspase-3, caspase-8, β-catenin, presenilin 1, and casein kinase II as well as other extracellular proteins including the EGF receptor.

Product Details
Isotype Control   Brilliant Violet 421™ Rat IgG1, κ IsotypeCtrl
Verified Reactivity   Mouse, Human
Reported Reactivity  Cynomolgus, Dog, Pig
Antibody Type  Monoclonal
Host Species  Rat
Immunogen  E-Cadherin extracellular domain
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).
Preparation
The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 421™ under optimal conditions.

Concentration  0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application
FC - Quality tested

Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Brilliant Violet 421™ excites at 405 nm and emits at 421 nm. The standard bandpass filter 450/50 nm is recommended for detection. Brilliant Violet 421™ is a trademark of Sirigen Group Ltd.

Learn more about Brilliant Violet™.

This product is subject to proprietary rights of Sirigen Inc. and is made and sold under license from Sirigen Inc. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents.
Excitation Laser  Violet Laser (405 nm)
Application Notes
Additional reported applications (for relevant formats) include: immunoprecipitation1, Western Blotting1, immunomicroscopy3, biological function1,2, and spatial biology (IBEX)4,5.

Antigen Details
Structure
Member of the cadherin superfamily. Calcium-dependent, transmembrane cell-cell adhesion glycoprotein composed of four extracellular cadherin repeats and a highly conserved cytoplasmic tail region.

Distribution
Widely expressed in epithelial cells in the colon, uterus, liver, keratinocytes, brain, heart, muscle, kidney, and pancreas as well as erythroid cells.

Function
Cell adhesion molecule involved in development, bacterial pathogenesis, and tumor invasion. The ectodomain of CD324 mediates bacterial adhesion to mammalian cells, while the cytoplasmic domain is required for internalization.
Interaction
Interacts with a variety of proteins including erbin, ezrin, caspase-3, caspase-8, EGF receptor, β-catenin, presenilin 1, casein kinase II, and others.
Ligand/Receptor αEβ7 integrin.
Cell Type  Embryonic Stem Cells
Biology Area
Cell Adhesion, Cell Biology, Immunology, Innate Immunity, Neuroscience, Stem Cells, Synaptic Biology
Molecular Family  Adhesion Molecules, CD Molecules

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