BioLegend 144620 PE/Cyanine7 anti-MU/HU GL7 Antigen (T/B Cell Act. Marker)

库存 ：99

英文名 ： PE/Cyanine7 anti-MU/HU GL7 Antigen (T/B Cell Act. Marker)

供应商 ：北京云肽生物科技有限公司

北京云肽生物科技有限公司作为BioLegend的特约经销商，为广大客户提供原装正品，货期短，折扣好的服务准则。

美国BioLegend公司位于美国加州，致力于为生物医药研究的各个前沿领域提供高质量的抗体及其它相关试剂。BioLegend虽然成立的时间不长，但它聚集了一批来自PharMingen公司的专业人士，建立了一支具有雄厚技术背景的专业队伍。通过其自身的先天优势，以及与世界知名实验室和研究所的良好合作关系，以合理的价格为广大客户提供高质量的免疫学和细胞生物学产品。BioLegend公司以其专业技术力量为保证，提供各种质量卓越的产品，并不断地开发新产品，以满足飞速发展的生命科学研究的需要。

BioLegend 144620 PE/Cyanine7 anti-MU/HU GL7 Antigen (T/B Cell Act. Marker)
产品简介：
产品品牌：BioLegend
产品货号：144620
产品名称：BioLegend 144620 PE/Cyanine7 anti-MU/HU GL7 Antigen (T/B Cell Act. Marker)
产品规格：100 µg

产品说明：
Clone  GL7 (See other available formats)
Regulatory Status  RUO
Other Names  Ly77, T and B cell activation marker
Isotype        Rat IgM, κ

描述
GL7抗原，也称为Ly77，是一种35kD的蛋白质。GL7抗原具有一个表位，该表位包含GL7抗体识别的非硫酸化α2-6-唾液酸-LacNAc。GL7抗原由前B细胞和未成熟B细胞、活化的T细胞和B细胞以及约20%的TCR明亮胸腺细胞表达。激活后在小鼠脾细胞上上调。它可能在调节或粘附中发挥作用。GL7高表达的B细胞显示出更高的抗体产生和抗原呈递能力。
The GL7 antigen, also known as Ly77, is a 35 kD protein.  The GL7 antigen has an epitope containing non-sulfated α2-6-sialyl-LacNAc recognized by the GL7 antibody. The GL7 antigen is expressed by pre-B and immature B cells, activated T and B cells, and about 20% of TCR-bright thymocytes.  It is upregulated on mouse splenocytes following activation.  It may play a role in regulation or adhesion.  GL7 high-expressing B cells show higher antibody production and antigen presenting capacity.

Product Details
Verified Reactivity  Mouse, Human
Antibody Type  Monoclonal
Host Species  Rat
Immunogen  LPS activated DBA/J mouse B cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Preparation
The antibody was purified by affinity chromatography and conjugated with PE/Cyanine7 under optimal conditions.
Concentration  0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application  FC - Quality tested

Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser  Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)

Application Notes
The GL7 antibody does not block the binding of CD22 with sulfated a2-6-sialyl-LacNAc.

Cross-reactivity to ferret has been reported by a collaborator, but not verified in house.

Additional Product Notes
BioLegend is in the process of converting the name PE/Cy7 to PE/Cyanine7. The dye molecule remains the same, so you should expect the same quality and performance from our PE/Cyanine7 products. Please contact Technical Service if you have any questions

Antigen Details
Structure  35 kD
Distribution
Germinal center B cells, activated B and T cells

Function  Upregulated on activated B cells via in situ repression of CMP-Neu5Ac-hydroxylase
Ligand/Receptor  Neu5Ac-recognizing lectins
Cell Type  B cells, T cells
Biology Area  Immunology, Innate Immunity
Molecular Family  CD Molecules

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