BioLegend 124508 PE anti-mouse CD276 (B7-H3)

库存 ：99

英文名 ： PE anti-mouse CD276 (B7-H3)

供应商 ：北京云肽生物科技有限公司

北京云肽生物科技有限公司作为BioLegend的特约经销商，为广大客户提供原装正品，货期短，折扣好的服务准则。

美国BioLegend公司位于美国加州，致力于为生物医药研究的各个前沿领域提供高质量的抗体及其它相关试剂。BioLegend虽然成立的时间不长，但它聚集了一批来自PharMingen公司的专业人士，建立了一支具有雄厚技术背景的专业队伍。通过其自身的先天优势，以及与世界知名实验室和研究所的良好合作关系，以合理的价格为广大客户提供高质量的免疫学和细胞生物学产品。BioLegend公司以其专业技术力量为保证，提供各种质量卓越的产品，并不断地开发新产品，以满足飞速发展的生命科学研究的需要。

BioLegend 124508  PE anti-mouse CD276 (B7-H3)
产品简介：
产品品牌：BioLegend
产品货号：124508
产品名称：BioLegend 124508 PE anti-mouse CD276 (B7-H3)
产品规格：100 µg

产品说明：
Clone  RTAA15 (See other available formats)
Regulatory Status  RUO
Other Names  B7H3, B7RP-2
Isotype  Rat IgG2a, κ

描述
B7-H3是B7基因家族的成员。它与人B7-H3具有88%的氨基酸序列同一性。它主要在专业APC上表达，包括B细胞、巨噬细胞和树突状细胞。其在树突状细胞上的表达似乎被LPS上调。B7-H3蛋白抑制T细胞活化和细胞因子的产生。据报道，抗B7-H3单克隆抗体在体外增强了T细胞的增殖，并导致体内EAE加剧。因此，B7-H3可能是T细胞活化和功能的负调控因子。
B7-H3 is a member of the B7 gene family. It has 88% amino acid sequence identity with human B7-H3. It is mostly expressed on professional APCs, including B cells, macrophages, and dendritic cells. Its expression on dendritic cells appears to be up-regulated by LPS. B7-H3 protein inhibits T cell activation and cytokine production. It was reported that monoclonal antibody against B7-H3 enhanced T cell proliferation in vitro and led to exacerbated EAE in vivo. Therefore, B7-H3 may be a negative regulator on T cell activation and function.

Product Details
Isotype Control  PE Rat IgG2a, κ Isotype Ctrl
Verified Reactivity  Mouse
Antibody Type  Monoclonal
Host Species  Rat
Formulation  Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation  The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration  0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application  FC - Quality tested
Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Excitation Laser  Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)

Antigen Details
Structure  About 49.7 kd transmembrane protein characterized by extracellular IgV and IgC domains.

Distribution
Mouse B7-H3 is expressed on professional APCs, including B cells, dendritic cells, and macrophages. It is reported to express on a minor fraction of CD4+ and CD8+ cells.
Ligand/Receptor
The receptor has not been identified, but it seems to be expressed on activated T cells.
Bioactivity
Mouse B7-H3 is a negative regulator of T cell activation and IL-2 production.
Cell Type   Antigen-presenting cells, Dendritic cells
Biology Area  Immunology, Costimulatory Molecules
Molecular Family  CD Molecules

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