BioLegend 119415 PE/Cyanine7 anti-mouse CD134 (OX-40)

库存 ：99

英文名 ：PE/Cyanine7 anti-mouse CD134 (OX-40)

供应商 ：北京云肽生物科技有限公司

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BioLegend 119415 PE/Cyanine7 anti-mouse CD134 (OX-40)
产品简介：
产品品牌：BioLegend
产品货号：119415
产品名称：BioLegend 119415 PE/Cyanine7 anti-mouse CD134 (OX-40)
产品规格：25 µg

产品说明：
Clone  OX-86 (See other available formats)
Regulatory Status  RUO
Other Names  TNFRSF4, ACT35, OX-40
Isotype  Rat IgG1, κ

描述
CD134是一种I型整合膜蛋白，也称为OX-40、ACT35和肿瘤坏死因子受体超家族成员4（TNFRSF4）。该受体在活化的CD4+和CD8+T细胞以及B细胞上表达。OX-40受体与OX-40配体（CD252）结合以提供独立于CD28的共刺激信号。阻断OX40-OX40配体相互作用已被证明可以改善实验性EAE和炎症性肠病，这意味着这些相互作用在某些自身免疫性疾病的发病机制中很重要。
CD134 is a type I integral membrane protein also known as OX-40, ACT35, and tumor necrosis factor receptor superfamily member 4 (TNFRSF4). This receptor is expressed on activated CD4+ and CD8+ T cells and B cells. The OX-40 receptor binds to the OX-40 ligand (CD252) to provide a costimulatory signal that is independent of CD28. Blockade of OX40-OX40 ligand interactions has been shown to ameliorate experimental EAE and inflammatory bowel disease, which implies that these interactions are important in the pathogenesis of some autoimmune diseases.

Product Details
Isotype Control   PE/Cyanine7 Rat IgG1, κ Isotype Ctrl
Verified Reactivity   Mouse
Antibody Type   Monoclonal
Host Species  Rat
Immunogen  Recombinant mouse OX-40-CD4 chimeric protein
Formulation  Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation  The antibody was purified by affinity chromatography and conjugated with PE/Cyanine7 under optimal conditions.
Concentration  0.2 mg/ml
Storage & Handling   The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application          FC - Quality tested
Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Excitation Laser  Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes
Clone OX-86 has been reported to act as an agonist and stimulate OX-40.
Additional Product Notes
BioLegend is in the process of converting the name PE/Cy7 to PE/Cyanine7. The dye molecule remains the same, so you should expect the same quality and performance from our PE/Cyanine7 products. Please contact Technical Service if you have any questions.

Antigen Details
Structure  TNF receptor superfamily, 50 kD
Distribution
Activated CD4+ and CD8+ T cells, activated B cells.

Function
Receptor for OX-40 ligand, provides co-stimulatory signal for lymphocyte proliferation independent of CD28; thought to play a role in the pathogenesis of some autoimmune diseases
Ligand/Receptor  OX-40 ligand
Cell Type  B cells, T cells, Tregs
Biology Area  Immunology
Molecular Family  CD Molecules, Immune Checkpoint Receptors

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