Anti-APC Antibody (Clone#OTI2B8)价格_品牌:BOSTER-丁香通官网

克隆性：Monoclonal

适应物种：human, mouse, rat

保质期：发货周期：5-7天

库存：9999

供应商：博士德生物

应用范围：WB, IHC

规格：50μl/100μl/150μl

产品概况

货号	MA00008
产品名称	Anti-APC Antibody (Clone#OTI2B8)
基因名	APC
抗体来源	Mouse
克隆	OTI2B8
抗体亚型	Mouse IgG1
分子量	311.5KD
免疫原	Human recombinant protein fragment corresponding to amino acids 955-1382 of human APC (NP_001120983) produced in E.coli.
内容	PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
纯化方式	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
浓度	500 ug/ml
产品形态	Liquid
保存条件	Stable for 12 months from date of receipt. Store at -20°C as received.
背景资料	This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008]
研究类别	1. Cathcart ES, Shirahama T, Cohen AS (1967). "Isolation and identification of a plasma component of amyloid". Biochim. Biophy. Acta 147: 392–393.2. "Entrez Gene: APCS amyloid P component, serum".3. Emsley J, White HE, O'Hara BP, Oliva G, Srinivasan N, Tickle IJ, Blundell TL, Pepys MB, Wood SP (1994). "Structure of pentameric human serum amyloid P component". Nature 367 (6461): 338–45.
Uniprot ID	APC: P25054

产品应用细节

博士德对每一批抗体都用没有转染过的细胞系和体细胞组织检测，以保证博士德出品的抗体有足够的亲和性足以和对应蛋白天然的表达含量起反应。

应用	稀释度*
Western blot (WB):	1:2000
Immunohistochemistry in paraffin section (IHC):	1:150

*最佳稀释度需要用户自己调试，此处数据仅供参考。

**博士德提供高敏感的二抗和检测试剂盒。详情见相关产品推荐。

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[list_product_images]Figure 1. Immunohistochemical staining of paraffin-embedded Human liver tissue within the normal limits using anti-APC mouse monoclonal antibody. (MA00008; heat-induced epitope retrieval by 1mM EDTA in 10mM Tris, pH8.5, 120°C for 3min)|Figure 2. Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-APC mouse monoclonal antibody. (MA00008; heat-induced epitope retrieval by 1mM EDTA in 10mM Tris, pH8.5, 120°C for 3min)|Figure 3. Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-APC mouse monoclonal antibody. (MA00008; heat-induced epitope retrieval by 1mM EDTA in 10mM Tris, pH8.5, 120°C for 3min)|Figure 4. Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-APC mouse monoclonal antibody. (MA00008; heat-induced epitope retrieval by 1mM EDTA in 10mM Tris, pH8.5, 120°C for 3min)|Figure 5. Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-APC mouse monoclonal antibody. (MA00008; heat-induced epitope retrieval by 1mM EDTA in 10mM Tris, pH8.5, 120°C for 3min)|Figure 6. Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-APC mouse monoclonal antibody. (MA00008; heat-induced epitope retrieval by 1mM EDTA in 10mM Tris, pH8.5, 120°C for 3min)|Figure 7. Human recombinant protein fragment corresponding to amino acids 955-1382 of human APC produced in E.coli.[/list_product_images]