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Simmitecan hydrochloride

CAS No. : 1247847-78-4

MCE 国际站：Simmitecan hydrochloride

产品活性：Simmitecan hydrochloride 是一种 9-取代的亲脂性喜树碱 (Camptothecin (HY-16560)) 衍生物，是一种有效的拓扑异构酶 I (topoisomerase I) 抑制剂。Simmitecan hydrochloride 是一种抗癌剂。

研究领域：Cell Cycle/DNA Damage  |  Metabolic Enzyme/Protease

作用靶点：Topoisomerase  |  Cytochrome P450

In Vitro: Simmitecan hydrochloride weak inhibitory effects on CYP2D6 (IC₅₀: 32.9 μM) and moderate inhibitory effects on CYP3A4 (IC₅₀: 8.95 μM).

In Vivo: Simmitecan hydrochloride (3.75, 7.5 and 15 mg/kg, i.v. bolus) shows mean elimination half-life t_1/2 of approximately 1.4 h in SD rats.

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