文献支持抗Rad9S1129酵母（泛反应性）（兔）抗体-600-401-346|Anti-Rad9 S1129 Yeast (pan reactive) (RABBIT) Antibody - 600-401-346

保存条件 ：Store vial at -20° C prior to opening.

保质期 ：1年

库存 ：100

供应商 ：艾美捷科技

宿主 ：兔

抗体英文名 ：Anti-Rad9 S1129 Yeast (pan reactive) (RABBIT) Antibody - 600-401-346

规格 ：100ug

Anti-Rad9 S1129 Yeast (pan reactive) (RABBIT) Antibody - 600-401-346，抗Rad9S1129酵母（泛反应性）（兔）抗体-600-401-346，抗Rad9S1129酵母（泛反应性）（兔）抗体-600-401-346,Anti-Rad9 S1129 Yeast (pan reactive) (RABBIT) Antibody - 600-401-346

产品名称：抗Rad9S1129酵母（泛反应性）（兔）抗体-600-401-346-Anti-Rad9 S1129 Yeast (pan reactive) (RABBIT) Antibody - 600-401-346

产品货号：600-401-346

产品规格：100ug

应用类型：ELISA,Western Blot,

保存建议：抗Rad9S1129酵母（泛反应性）（兔）抗体-600-401-346-Anti-Rad9 S1129 Yeast (pan reactive) (RABBIT) Antibody - 600-401-346Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

背景资料：Rad9 is required for the MEC1/TEL1-dependent activation of Saccharomyces cerevisiae DNA damage checkpoint pathways mediated by Rad53 and Chk1. DNA damage induces Rad9 phosphorylation, and Rad53 specifically associates with phosphorylated Rad9.  Cells have evolved multiple strategies for tolerating genomic damage. The most important of these are numerous repair systems that remove or bypass potentially mutagenic DNA lesions.  Another cellular strategy is to delay cell-cycle transitions at multiple points.  The genetic control of these delays, termed `checkpoints', was first established in budding yeast where it was shown that the RAD9 gene functions in G₂/M arrest after irradiation with X-rays.  Subsequently, it has become clear that Rad9 also functions at the G₁/S, intra-S and mid-anaphase checkpoints.  Defects in checkpoint regulation can lead to genome instability and, in higher eukaryotes, neoplastic transformation. Rad9 also controls the transcriptional induction of a DNA damage regulon (DDR).  Rad9 may also have a pro-apoptotic function.  This is suggested in that Rad9 from Schizosaccharomyces pombe (SpRad9) contains a group of amino acids with similarity to the Bcl-2 homology 3 death domain, which is required for SpRad9 interaction with human Bcl-2 and apoptosis induction in human cells.  Overexpression of Bcl-2 in S. pombe inhibits cell growth independently of rad9, but enhances resistance of rad9-null cells to methyl methanesulfonate, ultraviolet and ionizing radiation. Rad9 conveys the checkpoint signal by activating Rad53p and Chk1p; is hyperphosphorylated by Mec1p and Tel1p; and is a potential Cdc28p substrate. Mature yeast Rad9 is reported to have an apparent molecular weight of ~148kDa. The human homolog is reported at 48.5 kDa.

点击：抗Rad9S1129酵母（泛反应性）（兔）抗体-600-401-346-Anti-Rad9 S1129 Yeast (pan reactive) (RABBIT) Antibody - 600-401-346查看更详细产品说明，更多应用、储存、价格、货期等信息请致电027-59626688垂询艾美捷科技有限公司。更多Rockland公司特色试剂盒、特色抗体以及特色试剂等产品评论，请点击查看艾美捷特色产品中心。

Rockland成立于1962年，是一家老牌抗体原产企业，其位于美国费城郊区的农场保有近20种实验动物。Rockland公司为生命科学领域提供丰富的、高质量的抗体，包括载脂蛋白、细胞周期/凋亡、细胞因子、细胞信号蛋白、酶类、细胞外基质、转录因子(NFkB)和泛素（Ubiquitin）等识别抗体，应用范围包括Western blot、免疫组化、免疫荧光和ELISA等。另外，Rockland也生产特别齐全的二抗，包括纯化、生物素、HRP/ALP、荧光标记二抗，应用十分广泛。

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