P-P53(ser315)

亚型 ：IgG

形态 ：液体

保存条件 ：-20℃

克隆性 ：多克隆

标记物 ：无

适应物种 ：HMR

保质期 ：一年

抗原来源 ：兔

供应商 ：万类生物

宿主 ：兔

应用范围 ：WB

浓度 ：>1 mg/ml

靶点 ：P-P53(ser315)

抗体英文名 ：P-P53(ser315) antibody

抗体名 ：P-P53(ser315) 抗体

规格 ：50μl(>50μg)

产品概述

p53, a DNA-binding, oligomerization domain- and transcription activation domain-containing tumor suppressor, upregulates growth arrest and apoptosis-related genes in response to stress signals, thereby influencing programmed cell death, cell differentiation, and cell cycle control mechanisms. In vivo phosphorylation at Ser315 has been observed following UV-irradiation, and a Ser315Ala mutant p53 has reduced activity as a transcription factor . Aurora A phosphorylates p53 at Ser315 in a cell cycle-dependent manner leading to MDM2-mediated ubiquitination/degradation of p53.

更多产品详情，请咨询万类生物客服。