p-JNK (Thr183/Tyr185)

亚型 ：IgG

形态 ：液体

保存条件 ：-20℃

克隆性 ：多克隆

标记物 ：无

适应物种 ：HMR

保质期 ：一年

抗原来源 ：兔

供应商 ：万类生物

宿主 ：兔

应用范围 ：WB

浓度 ：>1 mg/ml

靶点 ：p-JNK (Thr183/Tyr185)

抗体英文名 ：p-JNK (Thr183/Tyr185) antibody

抗体名 ：p-JNK (Thr183/Tyr185) 抗体

规格 ：50μl(>50μg)

产品概述

c-Jun N-terminal kinases (JNKs) phosphorylate and augment transcriptional activity of c-Jun. JNKs originate from three genes that yield 10 isoforms through alternative mRNA splicing, including JNK1a1,JNK1b1, JNK2a1, JNK2b1, and JNK3a1, which represent the p46 isoforms, and JNK1a2, JNK1b2, JNK2a2, JNK2b2, and JNK3b2, which represent the p54 isoforms. JNKs coordinate cell responses to stress and influence regulation of cell growth and transformation. Members of the MAP kinase family are activated by dual phosphorylation at a Thr-Pro-Tyr motif, specifically at Thr-183 and Tyr-185 residues, in response to ultraviolet (UV) light. This motif is divergent from the Thr-Glu-Tyr motif characteristic of the MAP kinase family. JNK is phosphorylated by JNK-activating kinase (JNKK1 and JNKK2), which are members of the MEK family.

更多产品详情，请咨询万类生物客服。