p-erk1/2 (thr202/tyr204)

亚型 ：IgG

形态 ：液体

保存条件 ：-20℃

克隆性 ：多克隆

标记物 ：无

适应物种 ：HMR

保质期 ：一年

抗原来源 ：兔

供应商 ：万类生物

宿主 ：兔

应用范围 ：WB,IHC

浓度 ：>1 mg/ml

靶点 ：p-erk1/2 (thr202/tyr204)

抗体英文名 ：p-erk1/2 (thr202/tyr204) antibody

抗体名 ：p-erk1/2 (thr202/tyr204) 抗体

规格 ：50μl(>50μg)

产品概述

Extracellular signal-regulated kinases Erk1 (p44 MAPK) and Erk2 (p42 MAPK) Serine/Threonine protein kinase are part of a subfamily of mitogen-activated protein kinases. The p44/42 MAPK (Erk1/2) signaling pathway can be activated in response to a diverse range of extracellular stimuli including mitogens, growth factors and cytokines. Upon stimulation, a sequential three-part protein kinase cascade is initiated consisting of a MAP kinase kinase kinase (MAPKKK or MAP3K), a MAP kinase kinase (MAPKK or MAP2K) and a MAP kinase (MAPK). Phospho-ERK1/2 is negatively regulated by a family of dual-specificity (Thr/Tyr) MAPK phosphatases, known as DUSPs or MKPs (10), along with MEK inhibitors such as U0126 and PD98059.

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