NRF2

亚型 ：IgG

形态 ：液体

保存条件 ：-20℃

克隆性 ：多克隆

标记物 ：无

适应物种 ：HMR

保质期 ：一年

抗原来源 ：兔

供应商 ：万类生物

宿主 ：兔

应用范围 ：WB,IHC

浓度 ：>1 mg/ml

靶点 ：NRF2

抗体英文名 ：NRF2 antibody

抗体名 ：NRF2 抗体

规格 ：50μl(>50μg)

产品概述

The nuclear factor-like 2 (Nrf2) transcriptional activator binds antioxidant response elements (ARE) of target gene promoter regions to regulate expression of oxidative stress response genes. Under basal conditions, the Nrf2 inhibitor INrf2 (also called KEAP1) binds and retains Nrf2 in the cytoplasm where it can be targeted for ubiquitin-mediated degradation. Following oxidative or electrophilic stress, KEAP1 releases Nrf2, thereby allowing the activator to translocate to the nucleus and bind to ARE-containing genes. Altered expression of Nrf2 is associated with chronic obstructive pulmonary disease (COPD). Nrf2 activity in lung cancer cell lines directly correlates with cell proliferation rates, and inhibition of Nrf2 expression by siRNA enhances anti-cancer drug-induced apoptosis.

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