Caspase-1 p20

亚型 ：IgG

形态 ：液体

保存条件 ：-20℃

克隆性 ：多克隆

标记物 ：无

适应物种 ：HMR

保质期 ：一年

抗原来源 ：兔

供应商 ：万类生物

宿主 ：兔

应用范围 ：WB,IHC

浓度 ：＞1 mg/ml

抗体英文名 ：Caspase-1 p20 antibody

抗体名 ：Caspase-1 p20 抗体

规格 ：50μl(>50μg)

产品概述

Caspase-1, or interleukin-1ß converting enzyme (ICE/ICEα), is a class I cysteine protease, which also includes caspases -4, -5, -11, and -12. Caspase-1 promotes maturation of interleukin IL-1∫ and interleukin18 (IL-18) by proteolytic cleavage of precursor forms into biologically active pro-inflamatory cytokines. Active caspase-1, a (p20/p10)2 tetramer, is necessary and sufficient for cleavage of precursor IL-1 as well as for induction of apoptosis in some cell lines. The human Caspase-1 gene maps to chromosome 2q14 and encodes a cytoplasmic protein expressed in liver, heart, skeletal muscle kidney and testis. Caspase-1 has been implicated in inflammation, septic shock, and other situations such as wound healing and the growth of certain leukemias.

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