Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
亚细胞定位
Cytoplasm Nucleus
免疫原
Synthetic Peptide
亚型
IgG1
纯化方法
Affinity purification
克隆号
1H1
背景资料
This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
克隆类型
Monoclonal Antibody
交叉反应
Human Rat Mouse
应用
IHC
规格
50ul 100ul
备注:
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
实验图
Immunohistochemistry of paraffin-embedded Human prostate cancer with MMP2 antibody diluted at 1:200
Immunohistochemistry of paraffin-embedded Human stomach cancer with MMP2 antibody diluted at 1:200