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Tubulin inhibitor 30

CAS No. : 2873383-67-4

MCE 国际站：Tubulin inhibitor 30

产品活性：Tubulin inhibitor 30 (Compound 15) 是一种 tubulin 组合抑制剂，IC₅₀ 为 0.52 μM。Tubulin inhibitor 30 可以诱导 ferroptosis。

研究领域：Cell Cycle/DNA Damage  |  Cytoskeleton  |  Apoptosis

作用靶点：Microtubule/Tubulin  |  Ferroptosis

In Vitro: Tubulin inhibitor 30 (Compound 15) (0-100 nM; 48 h) inhibits the viability of MCF-7, U-87 MG and OVCAR-3 cells.
Tubulin inhibitor 30 is metabolically stable when incubated with human liver microsomes.

In Vivo: Tubulin inhibitor 30 (Compound 15) (25mg/kg; i.p.; every 2 days) inhibits the in vivo tumorigenicity of the human GBM cell line U-87 MG and the human OC cell line SKOV-3, and causes oxidative stress injury and Fe²⁺ accumulation in mice.

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