文献支持Rabbit anti-Bax Polyclonal Antibody，Bax抗体

免疫原 ：A synthesized peptide derived from Human BAX(Accession Q07812), corresponding to amino acid residues D53-I80.

亚型 ：-

形态 ：液态

保存条件 ：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles

克隆性 ：-

标记物 ：-

适应物种 ：Human, Mouse, Rat

保质期 ：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles

抗原来源 ：-

目录编号 ：-

级别 ：-

库存 ：现货

供应商 ：爱必信(上海)生物科技有限公司

宿主 ：Rabbit

应用范围 ：WB: 1:500~1:3000, IHC: 1:50~1:200, IF 1:200, ELISA(peptide) 1:20000-1:40000

浓度 ：1mg/ml

靶点 ：-

抗体英文名 ：Rabbit anti-Bax Polyclonal Antibody

抗体名 ：Bax抗体

规格 ：100ug/50ug

概述
描述	Bax Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Induces the release of cytochrome c, activation of CASP3, and thereby apoptosis. Belongs to the Bcl-2 family. Homodimer. Forms heterodimers with BCL2, E1B 19K protein, BCL2L1 isoform Bcl-X(L), MCL1 and A1. Interacts with SH3GLB1 and HN. Interacts with SFN and YWHAZ; the interaction occurs in the cytoplasm. Under stress conditions, JNK-mediated phosphorylation of SFN and YWHAZ, releases BAX to mitochondria. Isoform Sigma interacts with BCL2A1 and BCL2L1 isoform Bcl-X(L). 8 isoforms of the human protein are produced by alternative splicing.
别名	Bax抗体;Apoptosis regulator BAX; BAX; Bax-protein; BAX_HUMAN; BAXA; Baxdelta2G9; Baxdelta2G9omega; Baxdelta2omega; Bcl-2-like protein 4; BCL2 associated X protein; BCL2 associated X protein omega; BCL2 associated X protein transcript variant delta2; Bcl2-L-4; BCL2L4; membrane isoform alpha;
宿主	Rabbit
特异性	Bax antibody detects endogenous levels of total Bax.
反应种属	Human, Mouse, Rat
预测反应种属	Rabbit;Pig;Dog;Bovine;Horse
应用	WB: 1:500~1:3000, IHC: 1:50~1:200, IF 1:200, ELISA(peptide) 1:20000-1:40000
分子量	Predicted molecular weight: 21kD Disclaimer note: The obs  erved molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
免疫原	A synthesized peptide derived from Human BAX(Accession Q07812), corresponding to amino acid residues D53-I80.
性能
浓度	1mg/ml
纯化方法	The antiserum was purified by peptide aff  inity chromatography using SulfoLink™ Coupling Resin .
类型	Polyclonal Antibody
储存/保存方法	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
存储溶液	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
靶标
背景说明	Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
组织特异性	Expressed in a wide variety of tissues. Isoform Psi is found in glial tumors. Isoform Alpha is expressed in spleen, breast, ovary, testis, colon and brain, and at low levels in skin and lung. Isoform Sigma is expressed in spleen, breast, ovary, testis, lung, colon, brain and at low levels in skin. Isoform Alpha and isoform Sigma are expressed in pro-myelocytic leukemia, histiocytic lymphoma, Burkitt's lymphoma, T-cell lymphoma, lymphoblastic leukemia, breast adenocarcinoma, ovary adenocarcinoma, prostate carcinoma, prostate adenocarcinoma, lung carcinoma, epidermoid carcinoma, small cell lung carcinoma and colon adenocarcinoma cell lines.
细胞定位	Cytosol;Endoplasmic reticulum;Extracellular region or secreted;Mitochondrion;Nucleus;
UniProt	Q07812