文献支持Rabbit Anti-BLM/Blooms Syndrome Protein Blm Polyclonal Antibody,BLM抗体, Blooms Syndrome Protein Blm抗体

抗体名 ：BLM抗体

抗体英文名 ：-

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浓度 ：-

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适应物种 ：-

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抗原来源 ：-

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级别 ：-

库存 ：现货

供应商 ：爱必信(上海)生物科技有限公司

标记物 ：-

克隆性 ：-

保存条件 ：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

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亚型 ：-

免疫原 ：-

规格 ：100ul

别名	BLM抗体, Blooms Syndrome Protein Blm抗体;Blooms Syndrome Protein Blm, BLM, BLM_HUMAN, Bloom Syndrome, Bloom syndrome protein, Bloom syndrome RecQ helicase like, BS, DNA Helicase, DNA helicase RecQ like type 2, MGC126616, MGC131618, MGC131620, RECQ 2, RECQ like, RecQ like type 2, RecQ protein like 3, RecQ Protein-like 3, RECQ-2, RECQ-Like, RecQ-like type 2, RECQ2, RECQL 2, RECQL 3, RECQL-2, RECQL-3, RECQL2, RECQL3, type 2. , ,
宿主	Rabbit
特异性	BLM
预测反应种属	Human;Mouse;Rat;Dog;Pig;Cow;Horse;Sheep;
应用	WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
分子量	Predicted molecular weight: 159kDa Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
免疫原	KLH conjugated synthetic peptide derived from human BLM/Blooms Syndrome Protein Blm:1201-1417/1417
浓度	1mg/ml
纯化方法	affinity purified by Protein A
类型	Polyclonal Antibody
同种型	IgG
储存/保存方法	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
存储溶液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
研究领域	细胞生物  发育生物学  表观遗传学
背景说明	Bloom’s syndrome is an autosomal recessive disorder characterized by pre- and post-natal growth deficiencies, sun sensitivity, immunodeficiency and a predisposition to various cancers. The gene responsible for Bloom’s syndrome, BLM, encodes a protein homologous to the RecQ helicase of E. coli and is mutated in most Bloom’s syndrome patients. One characteristic of Bloom’s syndrome is an increased frequency of sister chromatid exchange (SCE). BLM has been shown to unwind G4 DNA, and a failure of this function is thought to be responsible for the increased rate of SCE. BLM is known to be translocated to the nucleus, where its ATPase activity is stimulated by both single- and double-stranded DNA. Mutations in the yeast SGS1, a homolog of BLM, are known to cause mitotic hyperrecombination similiar to that observed in Bloom’s cells.
细胞定位	细胞核
UniProt	P54132