文献支持Rabbit Anti-FXR/Bile Acid Receptor NR1H4 Polyclonal Antibody,FXR抗体, Bile Acid Receptor NR1H4抗体

抗体名 ：FXR抗体

抗体英文名 ：-

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浓度 ：-

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适应物种 ：-

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抗原来源 ：-

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库存 ：现货

供应商 ：爱必信(上海)生物科技有限公司

标记物 ：-

克隆性 ：-

保存条件 ：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

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亚型 ：-

免疫原 ：-

规格 ：100ul/50ul

别名	FXR抗体, Bile Acid Receptor NR1H4抗体;Bile Acid Receptor NR1H4, BAR, FXR, Farnesoid X activated receptor, Farnesoid X receptor, Farnesoid X-activated receptor, Farnesol receptor HRR 1, Farnesol receptor HRR-1, Farnesol receptor HRR1, FXR, HRR 1, HRR1, NR1H4, NR1H4_HUMAN, Nuclear receptor subfamily 1 group H member 4, Retinoid X receptor interacting protein 14, Retinoid X receptor-interacting protein 14, RIP 14, RIP14, RXR interacting protein 14, RXR-interacting protein 14. , ,
宿主	Rabbit
特异性	NR1H4
反应种属	Human;Mouse;
预测反应种属	Rat;Dog;Pig;Cow;Horse;Sheep;
应用	WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
分子量	Predicted molecular weight: 56kDa Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
免疫原	KLH conjugated synthetic peptide derived from human FXR/Bile Acid Receptor NR1H4:175-280/486
浓度	1mg/ml
纯化方法	affinity purified by Protein A
类型	Polyclonal Antibody
同种型	IgG
储存/保存方法	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
存储溶液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
研究领域	肿瘤  细胞生物  信号转导  新陈代谢  表观遗传学
背景说明	The steroid receptor superfamily acts through direct association with DNA sequences known as hormone response elements (HREs) and binds DNA as either homo- or heterodimers. The promiscuous mediator of heterodimerization, RXR, is the receptor for 9-cis retinoic acid, and dimerizes with VDR, TR, PPAR, and several novel receptors including LXR (also referred to as RLD-1) and FXR. FXR and LXR fall into a category of proteins termed “orphan receptors” because of their lack of a defined function, and in the case of LXR, the lack of a defined ligand. FXR has been shown to bind a class of lipid molecules called farnesoids. LXR/RXR heterodimers have highest affinity for DR-4 DNA elements while FXR/RXR heterodimers bind IR-1 elements. Both LXR/RXR and FXR/RXR heterodimers retain their responsiveness to 9-cis retinoic acid.
细胞定位	细胞核
UniProt	Q96RI1