Myriocin (ISP-1),35891-70-4

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产品名称：Myriocin (ISP-1)

产品别名：见爱必信官网

英文别名：Myriocin (ISP-1)

靶点：Others

CAS：35891-70-4

纯度：98%

外观：见爱必信官网

保存方法：Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

描述：

Myriocin is a small-molecule inhibitor of serine palmitoyltransferase (SPTLC), isolated from the Mycelia sterilia thermophilic fungus, with immunosuppressive properties. SPTLC is responsible for catalyzing the committed step of sphingolipid biosynthesis; inhibition of this activity by myriocin leads to a depletion of sphingolipid levels in the cell. Apoptosis of interleukin-2-dependent cytotoxic T cells (CTLL-2) is induced by exposure to myriocin, and because this observed cell death is suspendable with addition of sphingosine, it is suggested that cellular levels of sphingolipids are important for signaling the onset of and escape from apoptosis in CTLL-2 T cells. This same observation indicates a mechanism for the immunosuppression associated with myriocin. Inhibition of sphingolipid production by myriocin is thought to disturb the composition of the lipid raft structure crucial for hepatitis C virus replication, indirectly suppressing proliferation of the virus. Adhesion to the extracellular matrix is shown to be disrupted in cells depleted of sphingolipids, and myriocin represents a tool for studying such behaviors of cells in sphingolipid-depleted states.

溶解性：Soluble in DMSO (heat briefly in boiling water bath) (25 mg/ml), dilute base (50 mM NaOH) (~5 mg/ml), and methanol (2 mg/ml). Insoluble in water.

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