产品详情
文献和实验
相关推荐
保存条件 :Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
库存 :99
供应商 :爱必信(上海)生物科技有限公司
CAS号 :898800-26-5
规格 :5mg/1mg
公告提醒:爱必信所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)!
抑制剂描述: 产品名称:AZ876 产品别名:见爱必信官网 英文别名:AZ876 靶点:LXR CAS:898800-26-5 纯度: 外观:见爱必信官网 保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. 描述:AZ876 is a novel high-affinity LXR agonist. AZ876 was 25-fold and 2.5-fold more potent than GW3965 (HY-10627) on human (h)LXRα and hLXRβ respectively.(1) AZ876 suppressed up-regulation of hypertrophy- and fibrosis-related genes, and further inhibited prohypertrophic and profibrotic transforming growth factor β (TGFβ)-Smad2/3 signalling.(2) AZ876 prevented TGFβ- and angiotensin II-induced fibroblast collagen synthesis, and inhibited up-regulation of the myofibroblastic marker, α-smooth muscle actin.(3) The reference for administration is 20 umol/kg/day in vivo. 溶解性:DMSO: ≥ 2.6 mg/mL 体外研究: 体内研究: 产品信息订购:
absin,您身边的科研百宝箱 |
爱必信(上海)生物科技有限公司
品牌商实名认证
钻石会员
入驻年限:12年